| 9/4/2021 | Gustavus Adolphus | 80 | at | Buena Vista | 58 | MIA | ||
| Coe | 38 | at | Cornell IA | 7 | @ MidW | |||
| Marietta | 25 | at | Dubuque | 30 | OAC | |||
| Simpson | 6 | at | Mary Hardin-Baylor | 84 | @ ASWC | |||
| Eureka | 20 | at | Nebraska Wesleyan | 69 | NAC | |||
| Loras | 14 | at | St Norbert | 21 | @ NAC | |||
| Central IA | 46 | at | St Olaf | 27 | @ MIA | |||
| Luther | 14 | at | Wisconsin-Eau Claire | 45 | @ WIAC | |||
| Monmouth IL | 3 | at | Wartburg | 44 | MidW | |||
| 9/11/2021 | Nebraska Wesleyan | 20 | at | Augsburg | 19 | @ MIA | ||
| Kalamazoo | 13 | at | Central IA | 69 | MIAA | |||
| Hope | 21 | at | Coe | 28 | MIAA | |||
| Wartburg | 18 | at | Gustavus Adolphus | 27 | @ MIA | |||
| Wisconsin-Eau Claire | 28 | at | Loras | 6 | WIAC | |||
| St Olaf | 19 | at | Luther | 7 | MIA | |||
| Buena Vista | 58 | at | Northwestern MN | 21 | @ UMWAC | |||
| Wisconsin-Stevens Point | 34 | at | Simpson | 7 | WIAC | |||
| Dubuque | 7 | at | Wisconsin-La Crosse | 38 | @ WIAC | |||
| 9/18/2021 | Nebraska Wesleyan | 7 | at | Central IA | 37 | |||
| Simpson | 22 | at | Coe | 42 | ||||
| Buena Vista | 34 | at | Loras | 55 | ||||
| Dubuque | 28 | at | Luther | 2 | ||||
| 9/25/2021 | Luther | 14 | at | Buena Vista | 32 | |||
| Loras | 31 | at | Nebraska Wesleyan | 30 | ||||
| Central IA | 84 | at | Simpson | 16 | ||||
| Coe | 7 | at | Wartburg | 28 | ||||
| 10/2/2021 | Wartburg | 24 | at | Central IA | 49 | |||
| Buena Vista | 16 | at | Dubuque | 31 | ||||
| Simpson | 13 | at | Loras | 21 | ||||
| Nebraska Wesleyan | 28 | at | Luther | 21 | ||||
| 10/9/2021 | Central IA | 55 | at | Coe | 21 | |||
| Dubuque | 31 | at | Nebraska Wesleyan | 14 | ||||
| Luther | 34 | at | Simpson | 68 | ||||
| Loras | 21 | at | Wartburg | 58 | ||||
| 10/16/2021 | Nebraska Wesleyan | 7 | at | Buena Vista | 50 | |||
| Simpson | 28 | at | Dubuque | 41 | ||||
| Coe | 27 | at | Loras | 20 | ||||
| Wartburg | 67 | at | Luther | 0 | ||||
| 10/23/2021 | Loras | 19 | at | Central IA | 53 | |||
| Luther | 7 | at | Coe | 63 | ||||
| Buena Vista | 50 | at | Simpson | 19 | ||||
| Dubuque | 7 | at | Wartburg | 27 | ||||
| 10/30/2021 | Wartburg | 20 | at | Buena Vista | 24 | |||
| Coe | 34 | at | Dubuque | 27 | ||||
| Central IA | 76 | at | Luther | 13 | ||||
| Simpson | 14 | at | Nebraska Wesleyan | 44 | ||||
| 11/6/2021 | Dubuque | 7 | at | Central IA | 56 | |||
| Buena Vista | 28 | at | Coe | 31 | ||||
| Luther | 6 | at | Loras | 69 | ||||
| Nebraska Wesleyan | 14 | at | Wartburg | 50 | ||||
| 11/13/2021 | Central IA | 65 | at | Buena Vista | 6 | |||
| Loras | 14 | at | Dubuque | 17 | ||||
| Coe | 53 | at | Nebraska Wesleyan | 21 | ||||
| Wartburg | 55 | at | Simpson | 23 | ||||
| 11/20/2021 | Bethel MN | 35 | at | Central IA | 61 | MIA | ||
| 11/27/2021 | Wheaton | 28 | at | Central IA | 30 | CCIW | ||
| 12/4/2021 | Central IA | 21 | at | Wisconsin-Whitewater | 51 | @ WIAC |