| 9/4/2021 | Marietta | 25 | at | Dubuque (6-4) | 30 | at ARC | ||
| 9/18/2021 | Muskingum (5-5,4-5) | 0 | at | Marietta | 18 | |||
| 9/25/2021 | Marietta | 37 | at | Capital (2-8,1-8) | 7 | |||
| 10/2/2021 | Marietta | 33 | at | Ohio Northern (4-6,3-6) | 34 | |||
| 10/9/2021 | Heidelberg (7-2,6-2) | 44 | at | Marietta | 21 | |||
| 10/16/2021 | Marietta | 35 | at | Wilmington (2-7,2-6) | 7 | |||
| 10/23/2021 | John Carroll (7-3,7-2) | 19 | at | Marietta | 10 | |||
| 10/30/2021 | Marietta | 21 | at | Baldwin-Wallace (8-2,7-2) | 24 | |||
| 11/6/2021 | Otterbein (1-9,1-8) | 7 | at | Marietta | 56 | |||
| 11/13/2021 | Mount Union (13-1,9-0) | 37 | at | Marietta | 7 |
| vs Marietta | vs Other Opponents | Marietta compared to OOs | |
| Record: | 6-4 | 49-43 | |
| Points Scored: | 20.90 | 29.36 | 8.46 |
| Points Allowed: | 26.30 | 27.24 | -0.94 |
| Margin: | -5.40 | 2.12 | 7.52 |
| Total Points: | 47.20 | 56.60 | -9.40 |