| 9/4/2021 | Eureka | 20 | at | Nebraska Wesleyan (4-6) | 69 | at ARC | ||
| 9/11/2021 | Olivet (7-3) | 42 | at | Eureka | 23 | MIAA | ||
| 9/18/2021 | Eureka | 58 | at | Rockford (2-8,1-7) | 57 | OT | ||
| 9/25/2021 | Eureka | 29 | at | Ill. Benedictine (8-2,7-1) | 49 | |||
| 10/2/2021 | Concordia IL (3-7,1-7) | 13 | at | Eureka | 38 | |||
| 10/9/2021 | Concordia WI (6-4,4-4) | 41 | at | Eureka | 32 | |||
| 10/16/2021 | Eureka | 7 | at | Aurora (8-3,8-0) | 49 | |||
| 10/23/2021 | Eureka | 41 | at | Wisconsin Lutheran (3-7,3-5) | 68 | |||
| 10/30/2021 | Lakeland (8-2,6-2) | 45 | at | Eureka | 16 | |||
| 11/6/2021 | St Norbert (5-5,4-4) | 70 | at | Eureka | 21 |
| vs Eureka | vs Other Opponents | Eureka compared to OOs | |
| Record: | 8-2 | 46-45 | |
| Points Scored: | 50.30 | 32.45 | -17.85 |
| Points Allowed: | 28.50 | 32.44 | -3.94 |
| Margin: | 21.80 | 0.01 | -21.79 |
| Total Points: | 78.80 | 64.89 | 13.91 |