9/5/2015 | Case Western Reserve | 30 | at | Chicago | 31 | | | @ SAA |
| Frostburg State | 52 | at | Geneva | 21 | | | NJAC |
| Westminster PA | 17 | at | Hiram | 9 | | | @ NCA |
| Grove City | 13 | at | Juniata | 26 | | | @ Cen |
| Bethany WV | 0 | at | Mount Union | 47 | | | @ OAC |
| Waynesburg | 35 | at | Muskingum | 10 | | | @ OAC |
| John Carroll | 26 | at | St Vincent | 3 | | | OAC |
| Allegheny | 21 | at | Thiel | 37 | | | NCA |
| St John Fisher | 0 | at | Thomas More | 48 | | | E8 |
| Carnegie Mellon | 24 | at | Washington U | 45 | | | @ SAA |
| Washington & Jefferson | 56 | at | Wooster | 10 | | | @ NCA |
9/12/2015 | Thiel | 16 | at | Bethany WV | 51 | | | |
| Geneva | 21 | at | Grove City | 16 | | | |
| Waynesburg | 21 | at | St Vincent | 28 | | | |
| Hanover | 7 | at | Thomas More | 84 | | | HCA |
| Westminster PA | 31 | at | Washington & Jefferson | 35 | | | |
9/19/2015 | Westminster PA | 38 | at | Bethany WV | 24 | | | |
| Washington & Jefferson | 38 | at | Carnegie Mellon | 14 | | | |
| St Vincent | 14 | at | Case Western Reserve | 49 | | | |
| Waynesburg | 24 | at | Geneva | 41 | | | |
| Thiel | 12 | at | Thomas More | 60 | | | |
9/26/2015 | Carnegie Mellon | 35 | at | Geneva | 7 | | | |
| St Vincent | 48 | at | Grove City | 28 | | | |
| Case Western Reserve | 41 | at | Thiel | 6 | | | |
| Bethany WV | 27 | at | Waynesburg | 14 | | | |
| Thomas More | 45 | at | Westminster PA | 14 | | | |
10/3/2015 | Case Western Reserve | 59 | at | Bethany WV | 20 | | | |
| Thiel | 14 | at | St Vincent | 65 | | | |
| Washington & Jefferson | 20 | at | Thomas More | 38 | | | |
| Grove City | 31 | at | Waynesburg | 35 | | | |
| Carnegie Mellon | 16 | at | Westminster PA | 26 | | | |
10/10/2015 | Bethany WV | 35 | at | Carnegie Mellon | 56 | | | |
| Waynesburg | 14 | at | Case Western Reserve | 45 | | | |
| Westminster PA | 49 | at | Thiel | 6 | | | |
| Geneva | 14 | at | Thomas More | 44 | | | |
| Grove City | 7 | at | Washington & Jefferson | 55 | | | |
10/17/2015 | Case Western Reserve | 20 | at | Geneva | 7 | | | |
| Carnegie Mellon | 44 | at | Grove City | 0 | | | |
| Thomas More | 42 | at | St Vincent | 28 | | | |
| Bethany WV | 42 | at | Washington & Jefferson | 66 | | | |
| Westminster PA | 24 | at | Waynesburg | 7 | | | |
10/24/2015 | Geneva | 15 | at | Bethany WV | 41 | | | |
| St Vincent | 14 | at | Carnegie Mellon | 31 | | | |
| Washington & Jefferson | 28 | at | Case Western Reserve | 35 | | | |
| Thomas More | 66 | at | Grove City | 14 | | | |
| Thiel | 15 | at | Waynesburg | 28 | | | |
10/31/2015 | Grove City | 26 | at | Bethany WV | 58 | | | |
| Washington U | 16 | at | Case Western Reserve | 34 | | | SAA |
| Washington & Jefferson | 34 | at | Geneva | 13 | | | |
| Carnegie Mellon | 73 | at | Thiel | 19 | | | |
| Waynesburg | 13 | at | Thomas More | 42 | | | |
| St Vincent | 14 | at | Westminster PA | 39 | | | |
11/7/2015 | Chicago | 7 | at | Carnegie Mellon | 52 | | | SAA |
| Thomas More | 36 | at | Case Western Reserve | 32 | | | |
| Westminster PA | 45 | at | Grove City | 7 | | | |
| Geneva | 27 | at | St Vincent | 34 | | | |
| Thiel | 28 | at | Washington & Jefferson | 65 | | | |
11/14/2015 | Case Western Reserve | 42 | at | Carnegie Mellon | 52 | | | |
| Bethany WV | 35 | at | St Vincent | 27 | | | |
| Grove City | 23 | at | Thiel | 28 | | | |
| Waynesburg | 23 | at | Washington & Jefferson | 45 | | | |
| Geneva | 0 | at | Westminster PA | 32 | | | |
11/21/2015 | Washington and Lee | 21 | at | Thomas More | 51 | | NCAA D3 Championship - First Round | ODC |
11/22/2015 | Bridgewater State MA | 13 | vs | Carnegie Mellon | 48 | | ECAC Legacy Bowl | vs MSCAC |
11/28/2015 | Thomas More | 27 | at | Wabash | 33 | | NCAA D3 Championship - Second Round | @ NCA |