| 9/5/2015 | Case Western Reserve (7-3) | 30 | at | Chicago | 31 | TPAC | ||
| 9/19/2015 | Chicago | 31 | at | Millsaps (3-7,2-6) | 27 | |||
| 9/26/2015 | Centre (8-2,6-2) | 30 | at | Chicago | 49 | |||
| 10/3/2015 | Chicago | 28 | at | Birmingham-Southern (5-5,3-5) | 14 | |||
| 10/10/2015 | Berry (7-3,6-2) | 24 | at | Chicago | 17 | OT | ||
| 10/17/2015 | Chicago | 21 | at | Rhodes (4-6,2-6) | 7 | |||
| 10/24/2015 | Hendrix (8-3,7-1) | 27 | at | Chicago | 21 | |||
| 10/31/2015 | Sewanee (1-9,0-8) | 0 | at | Chicago | 31 | |||
| 11/7/2015 | Chicago | 7 | at | Carnegie Mellon (8-3) | 52 | at TPAC | ||
| 11/14/2015 | Chicago | 23 | at | Washington U (6-4,5-3) | 37 |
| vs Chicago | vs Other Opponents | Chicago compared to OOs | |
| Record: | 4-6 | 53-39 | |
| Points Scored: | 24.80 | 29.73 | 4.93 |
| Points Allowed: | 25.90 | 25.09 | 0.81 |
| Margin: | -1.10 | 4.64 | 5.74 |
| Total Points: | 50.70 | 54.82 | -4.12 |