| 9/3/2015 | Stony Brook (5-5) | at | Toledo | CCD | CAAF (1AA) | |||
| 9/12/2015 | Toledo | 16 | vs | Arkansas (8-5) | 12 | Little Rock AR | vs SEC | |
| 9/19/2015 | Iowa State (3-9) | 23 | at | Toledo | 30 | OT | B12 | |
| 9/26/2015 | Arkansas State (9-4) | 7 | at | Toledo | 37 | SBC | ||
| 10/3/2015 | Toledo | 24 | at | Ball State (3-9,2-6) | 10 | |||
| 10/10/2015 | Kent State (3-9,2-6) | 7 | at | Toledo | 38 | |||
| 10/17/2015 | Eastern Michigan (1-11,0-8) | 20 | at | Toledo | 63 | |||
| 10/24/2015 | Toledo | 51 | at | Massachusetts (3-9,2-6) | 35 | |||
| 11/3/2015 | Northern Illinois (8-6,6-3) | 32 | at | Toledo | 27 | |||
| 11/10/2015 | Toledo | 28 | at | Central Michigan (7-6,6-2) | 23 | |||
| 11/17/2015 | Toledo | 44 | at | Bowling Green (10-4,8-1) | 28 | |||
| 11/27/2015 | Western Michigan (8-5,6-2) | 35 | at | Toledo | 30 | |||
| 12/22/2015 | Temple (10-4) | 17 | vs | Toledo | 32 | Boca Raton Bowl (Boca Raton FL) | AAC |
| vs Toledo | vs Other Opponents | Toledo compared to OOs | |
| Record: | 2-10 | 76-76 | |
| Points Scored: | 20.75 | 29.37 | 8.62 |
| Points Allowed: | 35.00 | 27.83 | 7.17 |
| Margin: | -14.25 | 1.54 | 15.79 |
| Total Points: | 55.75 | 57.20 | -1.45 |