| 9/1/2012 | McKendree | 13 | at | Tiffin (3-8) | 23 | at GLIAC | ||
| 9/8/2012 | Henderson State (10-1) | 47 | at | McKendree | 24 | GAC | ||
| 9/15/2012 | Missouri S&T (10-1,7-1) | 31 | at | McKendree | 0 | |||
| 9/22/2012 | McKendree | 14 | at | Indianapolis (10-3,8-0) | 45 | |||
| 9/29/2012 | McKendree | 41 | at | Kentucky Wesleyan (2-9,0-8) | 17 | |||
| 10/6/2012 | William Jewell (2-9,1-7) | 20 | at | McKendree | 35 | |||
| 10/13/2012 | McKendree | 19 | at | Quincy (3-8,3-5) | 38 | |||
| 10/20/2012 | McKendree | 23 | at | Urbana (7-4,5-3) | 31 | |||
| 11/3/2012 | Central State (4-7,4-4) | 13 | at | McKendree | 34 | |||
| 11/10/2012 | St Joseph's (6-5,5-3) | 24 | at | McKendree | 19 |
| vs McKendree | vs Other Opponents | McKendree compared to OOs | |
| Record: | 7-3 | 50-52 | |
| Points Scored: | 28.90 | 28.86 | -0.04 |
| Points Allowed: | 22.20 | 29.27 | -7.07 |
| Margin: | 6.70 | -0.41 | -7.11 |
| Total Points: | 51.10 | 58.13 | -7.03 |