| 8/30/2012 | Indianapolis | 14 | at | Ashland (11-1) | 37 | at GLIAC | ||
| 9/8/2012 | Indianapolis | 17 | at | Western Illinois (3-8) | 27 | at MVC | ||
| 9/15/2012 | Indianapolis | 35 | at | Quincy (3-8,3-5) | 7 | |||
| 9/22/2012 | McKendree (3-7,3-5) | 14 | at | Indianapolis | 45 | |||
| 9/29/2012 | Indianapolis | 54 | at | Missouri S&T (10-1,7-1) | 35 | |||
| 10/6/2012 | St Joseph's (6-5,5-3) | 0 | at | Indianapolis | 56 | |||
| 10/13/2012 | Central State (4-7,4-4) | 13 | at | Indianapolis | 45 | |||
| 10/20/2012 | Indianapolis | 45 | at | Kentucky Wesleyan (2-9,0-8) | 14 | |||
| 10/27/2012 | William Jewell (2-9,1-7) | 3 | at | Indianapolis | 48 | |||
| 11/3/2012 | Delta State (3-7) | 18 | at | Indianapolis | 33 | GSC | ||
| 11/10/2012 | Indianapolis | 31 | at | Urbana (7-4,5-3) | 24 | |||
| 11/17/2012 | Midwestern State (9-2) | 14 | at | Indianapolis | 31 | LSC | ||
| 11/24/2012 | Indianapolis | 7 | at | Colorado State -Pueblo (12-1) | 28 | D2 Playoffs | at RMAC |
| vs Indianapolis | vs Other Opponents | Indianapolis compared to OOs | |
| Record: | 3-10 | 72-59 | |
| Points Scored: | 18.00 | 28.60 | 10.60 |
| Points Allowed: | 35.46 | 27.12 | 8.34 |
| Margin: | -17.46 | 1.48 | 18.94 |
| Total Points: | 53.46 | 55.72 | -2.26 |