| 8/30/2012 | Indianapolis | 14 | at | Ashland | 37 | @ GLIAC | ||
| Walsh | 40 | at | Kentucky Wesleyan | 10 | vs GLIAC | |||
| St Joseph's | 36 | at | Valparaiso | 34 | @ Pio (1AA) | |||
| 8/31/2012 | Quincy | 31 | at | Northwood | 54 | @ GLIAC | ||
| 9/1/2012 | William Jewell | 16 | at | Colorado Mines | 57 | @ RMAC | ||
| Panhandle State | 14 | at | Missouri S&T | 55 | vs D2Ind | |||
| McKendree | 13 | at | Tiffin | 23 | @ GLIAC | |||
| Tusculum | 33 | at | Urbana | 53 | vs SAC | |||
| 9/2/2012 | Stillman | 28 | vs | Central State | 27 | Dayton OH | vs SIAC | |
| 9/6/2012 | Missouri S&T | 27 | at | Arkansas Tech | 19 | @ GAC | ||
| St Joseph's | 14 | at | Charleston WV | 33 | @ WVIAC | |||
| 9/8/2012 | Quincy | 0 | at | Indiana State | 44 | @ MVC (1AA) | ||
| Kentucky Wesleyan | 13 | at | Kentucky State | 6 | @ SIAC | |||
| Henderson State | 47 | at | McKendree | 24 | vs GAC | |||
| William Jewell | 0 | at | Missouri Western | 56 | @ MAIAA | |||
| Central State | 0 | at | Northern Iowa | 59 | @ MVC (1AA) | |||
| Seton Hill | 31 | at | Urbana | 34 | vs WVIAC | |||
| Indianapolis | 17 | at | Western Illinois | 27 | @ MVC (1AA) | |||
| 9/15/2012 | Urbana | 22 | at | Central State | 28 | |||
| Missouri S&T | 31 | at | McKendree | 0 | ||||
| Indianapolis | 35 | at | Quincy | 7 | ||||
| St Joseph's | 35 | at | Robert Morris IL | 40 | @ NAIAInd (NAIA) | |||
| Kentucky Wesleyan | 26 | at | William Jewell | 29 | ||||
| 9/22/2012 | McKendree | 14 | at | Indianapolis | 45 | |||
| Kentucky Wesleyan | 23 | at | Missouri S&T | 47 | ||||
| William Jewell | 48 | at | South Dakota Tech | 21 | @ D2Ind | |||
| Central State | 36 | at | St Joseph's | 42 | ||||
| Quincy | 10 | at | Urbana | 14 | ||||
| 9/29/2012 | McKendree | 41 | at | Kentucky Wesleyan | 17 | |||
| Indianapolis | 54 | at | Missouri S&T | 35 | ||||
| Quincy | 21 | at | St Joseph's | 24 | ||||
| Central State | 23 | at | William Jewell | 21 | ||||
| Urbana | 21 | at | West Virginia Wesleyan | 33 | @ WVIAC | |||
| 10/6/2012 | Missouri S&T | 27 | at | Central State | 21 | |||
| St Joseph's | 0 | at | Indianapolis | 56 | ||||
| Urbana | 74 | at | Kentucky Wesleyan | 0 | ||||
| William Jewell | 20 | at | McKendree | 35 | ||||
| Saint Ambrose | 34 | at | Quincy | 18 | vs MSFA (NAIA) | |||
| 10/13/2012 | Central State | 13 | at | Indianapolis | 45 | |||
| Lindenwood-Belleville | 35 | at | Kentucky Wesleyan | 42 | vs NAIAInd (NAIA) | |||
| William Jewell | 17 | at | Missouri S&T | 52 | ||||
| McKendree | 19 | at | Quincy | 38 | ||||
| Urbana | 37 | at | St Joseph's | 7 | ||||
| 10/20/2012 | Indianapolis | 45 | at | Kentucky Wesleyan | 14 | |||
| Missouri S&T | 64 | at | Quincy | 6 | ||||
| McKendree | 23 | at | Urbana | 31 | ||||
| St Joseph's | 65 | at | William Jewell | 49 | ||||
| 10/27/2012 | Quincy | 16 | at | Central State | 32 | |||
| William Jewell | 3 | at | Indianapolis | 48 | ||||
| St Joseph's | 38 | at | Kentucky Wesleyan | 27 | ||||
| Urbana | 12 | at | Missouri S&T | 13 | ||||
| 11/3/2012 | Delta State | 18 | at | Indianapolis | 33 | vs GSC | ||
| Central State | 13 | at | McKendree | 34 | ||||
| Kentucky Wesleyan | 27 | at | Quincy | 35 | ||||
| Missouri S&T | 41 | at | St Joseph's | 22 | ||||
| William Jewell | 7 | at | Urbana | 53 | ||||
| 11/10/2012 | Kentucky Wesleyan | 7 | at | Central State | 51 | |||
| St Joseph's | 24 | at | McKendree | 19 | ||||
| Missouri S&T | 66 | at | South Dakota Tech | 17 | @ D2Ind | |||
| Indianapolis | 31 | at | Urbana | 24 | ||||
| Quincy | 21 | at | William Jewell | 14 | ||||
| 11/17/2012 | Midwestern State | 14 | at | Indianapolis | 31 | vs LSC | ||
| Central State | 6 | at | Kentucky State | 17 | @ SIAC | |||
| 11/24/2012 | Indianapolis | 7 | at | Colorado State -Pueblo | 28 | D2 Playoffs | @ RMAC |