| 9/1/2012 | Charleston Southern | 14 | at | The Citadel (7-4) | 49 | at SoCon | ||
| 9/8/2012 | Jacksonville (7-4) | 31 | at | Charleston Southern | 10 | Pio | ||
| 9/15/2012 | Charleston Southern | 0 | at | Illinois (2-10) | 44 | at B10 | ||
| 9/22/2012 | Charleston Southern | 23 | at | Shorter (6-5) | 20 | at GSC | ||
| 10/6/2012 | Charleston Southern | 7 | at | Stony Brook (10-3,5-1) | 49 | |||
| 10/13/2012 | VMI (2-9,1-5) | 14 | at | Charleston Southern | 32 | |||
| 10/20/2012 | Presbyterian (2-9,0-6) | 21 | at | Charleston Southern | 31 | |||
| 10/27/2012 | Edward Waters (5-6) | 7 | at | Charleston Southern | 42 | NAIAInd (NAIA) | ||
| 11/3/2012 | Charleston Southern | 12 | at | Liberty (6-5,5-1) | 26 | |||
| 11/10/2012 | Gardner-Webb (3-8,2-4) | 10 | at | Charleston Southern | 28 | |||
| 11/17/2012 | Charleston Southern | 20 | at | Coastal Carolina (8-5,5-1) | 41 |
| vs Charleston Southern | vs Other Opponents | Charleston Southern compared to OOs | |
| Record: | 6-5 | 52-63 | |
| Points Scored: | 28.36 | 24.17 | -4.19 |
| Points Allowed: | 19.91 | 28.79 | -8.88 |
| Margin: | 8.45 | -4.62 | -13.07 |
| Total Points: | 48.27 | 52.96 | -4.69 |