| 9/1/2012 | Savannah State (1-10) | 0 | at | Oklahoma State | 84 | MEAC (1AA) | ||
| 9/8/2012 | Oklahoma State | 38 | at | Arizona (8-5) | 59 | at P12 | ||
| 9/15/2012 | UL Lafayette (9-4) | 24 | at | Oklahoma State | 65 | SBC | ||
| 9/29/2012 | Texas (9-4,5-4) | 41 | at | Oklahoma State | 36 | |||
| 10/13/2012 | Oklahoma State | 20 | at | Kansas (1-11,0-9) | 14 | |||
| 10/20/2012 | Iowa State (6-7,3-6) | 10 | at | Oklahoma State | 31 | |||
| 10/27/2012 | TCU (7-6,4-5) | 14 | at | Oklahoma State | 36 | |||
| 11/3/2012 | Oklahoma State | 30 | at | Kansas State (11-2,8-1) | 44 | |||
| 11/10/2012 | West Virginia (7-6,4-5) | 34 | at | Oklahoma State | 55 | |||
| 11/17/2012 | Texas Tech (8-5,4-5) | 21 | at | Oklahoma State | 59 | |||
| 11/24/2012 | Oklahoma State | 48 | at | Oklahoma (10-3,8-1) | 51 | OT | ||
| 12/1/2012 | Oklahoma State | 34 | at | Baylor (8-5,4-5) | 41 | |||
| 1/1/2013 | Purdue (6-7) | 14 | vs | Oklahoma State | 58 | Heart of Dallas Bowl | B10 |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 5-8 | 86-67 | |
| Points Scored: | 28.23 | 33.07 | 4.84 |
| Points Allowed: | 45.69 | 29.79 | 15.90 |
| Margin: | -17.46 | 3.28 | 20.74 |
| Total Points: | 73.92 | 62.86 | 11.06 |