| 9/1/2012 | Tulsa (11-3) | 23 | at | Iowa State | 38 | CUSA | ||
| 9/8/2012 | Iowa State | 9 | at | Iowa (4-8) | 6 | at B10 | ||
| 9/15/2012 | Western Illinois (3-8) | 3 | at | Iowa State | 37 | MVC (1AA) | ||
| 9/29/2012 | Texas Tech (8-5,4-5) | 24 | at | Iowa State | 13 | |||
| 10/6/2012 | Iowa State | 37 | at | TCU (7-6,4-5) | 23 | |||
| 10/13/2012 | Kansas State (11-2,8-1) | 27 | at | Iowa State | 21 | |||
| 10/20/2012 | Iowa State | 10 | at | Oklahoma State (8-5,5-4) | 31 | |||
| 10/27/2012 | Baylor (8-5,4-5) | 21 | at | Iowa State | 35 | |||
| 11/3/2012 | Oklahoma (10-3,8-1) | 35 | at | Iowa State | 20 | |||
| 11/10/2012 | Iowa State | 7 | at | Texas (9-4,5-4) | 33 | |||
| 11/17/2012 | Iowa State | 51 | at | Kansas (1-11,0-9) | 23 | |||
| 11/23/2012 | West Virginia (7-6,4-5) | 31 | at | Iowa State | 24 | |||
| 12/31/2012 | Iowa State | 17 | vs | Tulsa (11-3) | 31 | AutoZone Libserty Bowl | vs CUSA |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 7-6 | 90-62 | |
| Points Scored: | 23.92 | 34.37 | 10.45 |
| Points Allowed: | 24.54 | 29.03 | -4.49 |
| Margin: | -0.62 | 5.34 | 5.96 |
| Total Points: | 48.46 | 63.40 | -14.94 |