| 9/1/2012 | Eastern Kentucky (8-3) | 6 | at | Purdue | 48 | OVC (1AA) | ||
| 9/8/2012 | Purdue | 17 | at | Notre Dame (12-1) | 20 | at ND | ||
| 9/15/2012 | Eastern Michigan (2-10) | 16 | at | Purdue | 54 | MAC | ||
| 9/29/2012 | Marshall (5-7) | 41 | at | Purdue | 51 | CUSA | ||
| 10/6/2012 | Michigan (8-5,6-2) | 44 | at | Purdue | 13 | |||
| 10/13/2012 | Wisconsin (8-6,5-4) | 38 | at | Purdue | 14 | |||
| 10/20/2012 | Purdue | 22 | at | Ohio State (12-0,8-0) | 29 | OT | ||
| 10/27/2012 | Purdue | 28 | at | Minnesota (6-7,2-6) | 44 | |||
| 11/3/2012 | Penn State (8-4,6-2) | 34 | at | Purdue | 9 | |||
| 11/10/2012 | Purdue | 27 | at | Iowa (4-8,2-6) | 24 | |||
| 11/17/2012 | Purdue | 20 | at | Illinois (2-10,0-8) | 17 | |||
| 11/24/2012 | Indiana (4-8,2-6) | 35 | at | Purdue | 56 | |||
| 1/1/2013 | Purdue | 14 | vs | Oklahoma State (8-5) | 58 | Heart of Dallas Bowl | vs B12 |
| vs Purdue | vs Other Opponents | Purdue compared to OOs | |
| Record: | 7-6 | 80-68 | |
| Points Scored: | 31.23 | 29.05 | -2.18 |
| Points Allowed: | 28.69 | 25.68 | 3.01 |
| Margin: | 2.54 | 3.37 | 0.83 |
| Total Points: | 59.92 | 54.73 | 5.19 |