| 9/1/2012 | Notre Dame | 50 | vs | Navy | 10 | Dublin Ireland | @ Ind | |
| 9/8/2012 | Purdue | 17 | at | Notre Dame | 20 | vs B10 | ||
| 9/15/2012 | Notre Dame | 20 | at | Michigan State | 3 | @ B10 | ||
| 9/22/2012 | Michigan | 6 | at | Notre Dame | 13 | vs B10 | ||
| 10/6/2012 | Miami-Florida | 3 | vs | Notre Dame | 41 | Chicago IL | vs ACC | |
| 10/13/2012 | Stanford | 13 | at | Notre Dame | 20 | OT | vs P12 | |
| 10/20/2012 | BYU | 14 | at | Notre Dame | 17 | vs Ind | ||
| 10/27/2012 | Notre Dame | 30 | at | Oklahoma | 13 | @ B12 | ||
| 11/3/2012 | Pittsburgh | 26 | at | Notre Dame | 29 | 3OT | vs BigE | |
| 11/10/2012 | Notre Dame | 21 | at | Boston College | 6 | @ ACC | ||
| 11/17/2012 | Wake Forest | 0 | at | Notre Dame | 38 | vs ACC | ||
| 11/24/2012 | Notre Dame | 22 | at | Southern California | 13 | @ P12 | ||
| 1/7/2013 | Alabama | 42 | vs | Notre Dame | 14 | Discover BCS National Championship | vs SEC |