| 9/4/2010 | Western Oregon Runnin' Wolves 38 @ Simon Fraser 0 | † |
| 9/11/2010 | Southern Oregon Raiders 31 @ Simon Fraser 18 | |
| 9/18/2010 | Simon Fraser 25 @ Western Oregon Runnin' Wolves 48 | † |
| 9/25/2010 | Central Washington Wildcats 44 @ Simon Fraser 30 | † |
| 10/2/2010 | Dixie State Rebels 28 @ Simon Fraser 21 | † |
| 10/23/2010 | Simon Fraser 15 @ Dixie State Rebels 18 | † |
| 10/30/2010 | Humboldt State Lumberjacks 35 @ Simon Fraser 14 | † |
| 11/6/2010 | Simon Fraser 7 @ Central Washington Wildcats 34 | † |
| 11/13/2010 | Simon Fraser 20 @ Humboldt State Lumberjacks 66 | † |