| 9/4/2010 | Western Oregon 38 @ Simon Fraser Clan 0 | † |
| 9/11/2010 | Western Oregon 17 @ Sacramento State Hornets 31 | |
| 9/18/2010 | Simon Fraser Clan 25 @ Western Oregon 48 | † |
| 9/25/2010 | Humboldt State Lumberjacks 14 @ Western Oregon 7 | † |
| 10/2/2010 | Western Oregon 24 @ Southern Oregon Raiders 23 | |
| 10/9/2010 | Western Oregon 40 @ Dixie State Rebels 27 | † |
| 10/16/2010 | Western Oregon 0 vs Central Washington Wildcats 19 (Seattle WA) | † |
| 10/23/2010 | Azusa Pacific Cougars 17 @ Western Oregon 38 | |
| 10/30/2010 | Dixie State Rebels 7 @ Western Oregon 42 | † |
| 11/6/2010 | Western Oregon 26 @ Humboldt State Lumberjacks 24 | † |
| 11/13/2010 | Western Oregon 16 @ Central Washington Wildcats 21 | † |