| 9/11/2010 | Kansas Wesleyan 23 @ Tabor Bluejays 20 | † |
| 9/18/2010 | St Mary KS Spires 17 @ Kansas Wesleyan 59 | † |
| 9/25/2010 | Bethel KS Threshers 0 @ Kansas Wesleyan 45 | † |
| 10/2/2010 | Kansas Wesleyan 66 @ Bethany KS Terrible Swedes 49 | † |
| 10/9/2010 | Haskell Indians 7 @ Kansas Wesleyan 59 | |
| 10/16/2010 | Kansas Wesleyan 42 @ McPherson Bulldogs 56 | † |
| 10/23/2010 | Sterling Warriors 22 @ Kansas Wesleyan 21 | † |
| 10/30/2010 | Ottawa Braves 49 @ Kansas Wesleyan 45 | † |
| 11/6/2010 | Kansas Wesleyan 36 @ Friends Falcons 33 | † |
| 11/13/2010 | Kansas Wesleyan 72 @ Southwestern Moundbuilders 48 | † |