| 9/25/2010 | Wesleyan Cardinals 21 @ Middlebury 24 | † |
| 10/2/2010 | Middlebury 27 @ Colby White Mules 38 | † |
| 10/9/2010 | Amherst Lord Jeffs 38 @ Middlebury 31 | † |
| 10/16/2010 | Middlebury 17 @ Williams Ephs 41 | † |
| 10/23/2010 | Bates Bobcats 9 @ Middlebury 22 | † |
| 10/30/2010 | Middlebury 10 @ Trinity CT Bantams 25 | † |
| 11/6/2010 | Middlebury 30 @ Hamilton Continentals 26 | † |
| 11/13/2010 | Tufts Jumbos 20 @ Middlebury 42 | † |