| 9/25/2010 | Wesleyan 21 @ Middlebury Panthers 24 | † |
| 10/2/2010 | Hamilton Continentals 21 @ Wesleyan 35 | † |
| 10/9/2010 | Wesleyan 27 @ Colby White Mules 20 | † |
| 10/16/2010 | Wesleyan 27 @ Bates Bobcats 20 | † |
| 10/23/2010 | Amherst Lord Jeffs 37 @ Wesleyan 10 | † |
| 10/30/2010 | Bowdoin Polar Bears 7 @ Wesleyan 41 | † |
| 11/6/2010 | Wesleyan 7 @ Williams Ephs 45 | † |
| 11/13/2010 | Trinity CT Bantams 27 @ Wesleyan 20 | † |