| 9/25/2010 | Colby 6 @ Trinity CT Bantams 33 | † |
| 10/2/2010 | Middlebury Panthers 27 @ Colby 38 | † |
| 10/9/2010 | Wesleyan Cardinals 27 @ Colby 20 | † |
| 10/16/2010 | Colby 3 @ Amherst Lord Jeffs 30 | † |
| 10/23/2010 | Hamilton Continentals 7 @ Colby 35 | † |
| 10/30/2010 | Colby 10 @ Bates Bobcats 6 | † |
| 11/6/2010 | Colby 42 @ Tufts Jumbos 41 | † |
| 11/13/2010 | Bowdoin Polar Bears 26 @ Colby 21 | † |