| 9/25/2010 | Hamilton Continentals 10 @ Tufts 21 | † |
| 10/2/2010 | Bates Bobcats 21 @ Tufts 20 | † |
| 10/9/2010 | Tufts 15 @ Bowdoin Polar Bears 22 | † |
| 10/16/2010 | Tufts 7 @ Trinity CT Bantams 27 | † |
| 10/23/2010 | Williams Ephs 35 @ Tufts 24 | † |
| 10/30/2010 | Tufts 49 @ Amherst Lord Jeffs 70 | † |
| 11/6/2010 | Colby White Mules 42 @ Tufts 41 | † |
| 11/13/2010 | Tufts 20 @ Middlebury Panthers 42 | † |