| 9/5/2009 | Montana St 3 @ Michigan St 44 | |
| 9/12/2009 | Central Michigan 29 @ Michigan St 27 | |
| 9/19/2009 | Michigan St 30 @ Notre Dame 33 | |
| 9/26/2009 | Michigan St 30 @ Wisconsin 38 | † |
| 10/3/2009 | Michigan 20 @ Michigan St 26 1OT | † |
| 10/10/2009 | Michigan St 24 @ Illinois 14 | † |
| 10/17/2009 | Northwestern 14 @ Michigan St 24 | † |
| 10/24/2009 | Iowa 15 @ Michigan St 13 | † |
| 10/31/2009 | Michigan St 34 @ Minnesota 42 | † |
| 11/7/2009 | Western Michigan 14 @ Michigan St 49 | |
| 11/14/2009 | Michigan St 40 @ Purdue 37 | † |
| 11/21/2009 | Penn State 42 @ Michigan St 14 | † |
| 1/2/2010 | Michigan St 31 vs Texas Tech 41 (Alamo Bowl) |