| 9/5/2009 | Western Michigan 7 @ Michigan 31 | |
| 9/12/2009 | Notre Dame 34 @ Michigan 38 | |
| 9/19/2009 | Eastern Michigan 17 @ Michigan 45 | |
| 9/26/2009 | Indiana 33 @ Michigan 36 | † |
| 10/3/2009 | Michigan 20 @ Michigan St 26 1OT | † |
| 10/10/2009 | Michigan 28 @ Iowa 30 | † |
| 10/17/2009 | Delaware St 6 @ Michigan 63 | |
| 10/24/2009 | Penn State 35 @ Michigan 10 | † |
| 10/31/2009 | Michigan 13 @ Illinois 38 | † |
| 11/7/2009 | Purdue 38 @ Michigan 36 | † |
| 11/14/2009 | Michigan 24 @ Wisconsin 45 | † |
| 11/21/2009 | Ohio State 21 @ Michigan 10 | † |