| 9/5/2009 | North Dakota 13 @ Texas Tech 38 | |
| 9/12/2009 | Rice 10 @ Texas Tech 55 | |
| 9/19/2009 | Texas Tech 24 @ Texas 34 | † |
| 9/26/2009 | Texas Tech 28 @ Houston 29 | |
| 10/3/2009 | New Mexico 28 @ Texas Tech 48 | |
| 10/10/2009 | Kansas St 14 @ Texas Tech 66 | † |
| 10/17/2009 | Texas Tech 31 @ Nebraska 10 | † |
| 10/24/2009 | Texas A&M 52 @ Texas Tech 30 | † |
| 10/31/2009 | Kansas 21 @ Texas Tech 42 | † |
| 11/14/2009 | Texas Tech 17 @ Oklahoma St 24 | † |
| 11/21/2009 | Oklahoma 13 @ Texas Tech 41 | † |
| 11/28/2009 | Texas Tech 20 vs Baylor 13 (Arlington TX) | † |
| 1/2/2010 | Michigan St 31 vs Texas Tech 41 (Alamo Bowl) |