| 9/12/2020 | The Citadel (0-4) | 6 | at | South Florida | 27 | SoCon (1AA) | ||
| 9/19/2020 | South Florida | 0 | at | Notre Dame (3-0) | 52 | at ACC | ||
| 10/3/2020 | South Florida | 7 | at | Cincinnati (3-0,1-0) | 28 | |||
| 10/10/2020 | East Carolina (1-2,1-1) | 44 | at | South Florida | 24 | |||
| 10/17/2020 | South Florida | at | Temple (0-1,0-1) | |||||
| 10/23/2020 | Tulsa (1-1,1-0) | at | South Florida | |||||
| 11/7/2020 | South Florida | at | Memphis (1-1,0-1) | |||||
| 11/14/2020 | South Florida | at | Houston (1-0,1-0) | |||||
| 11/21/2020 | Navy (2-2,2-0) | at | South Florida | |||||
| 11/27/2020 | UCF (2-1,1-1) | at | South Florida |
| vs South Florida | vs Other Opponents | South Florida compared to OOs | |
| Record: | 3-1 | 11-11 | |
| Points Scored: | 32.50 | 27.50 | -5.00 |
| Points Allowed: | 14.50 | 29.91 | -15.41 |
| Margin: | 18.00 | -2.41 | -20.41 |
| Total Points: | 47.00 | 57.41 | -10.41 |