| 9/26/2020 | UCF (2-1,1-1) | 51 | at | East Carolina | 28 | |||
| 10/3/2020 | East Carolina | 29 | at | Georgia State (1-2) | 49 | at SBC | ||
| 10/10/2020 | East Carolina | 44 | at | South Florida (1-3,0-2) | 24 | |||
| 10/17/2020 | Navy (2-2,2-0) | at | East Carolina | |||||
| 10/30/2020 | East Carolina | at | Tulsa (1-1,1-0) | |||||
| 11/7/2020 | Tulane (2-2,0-2) | at | East Carolina | |||||
| 11/13/2020 | East Carolina | at | Cincinnati (3-0,1-0) | |||||
| 11/21/2020 | East Carolina | at | Temple (0-1,0-1) | |||||
| 11/28/2020 | SMU (4-0,1-0) | at | East Carolina |
| vs East Carolina | vs Other Opponents | East Carolina compared to OOs | |
| Record: | 2-1 | 14-11 | |
| Points Scored: | 41.33 | 30.44 | -10.89 |
| Points Allowed: | 33.67 | 28.36 | 5.31 |
| Margin: | 7.66 | 2.08 | -5.58 |
| Total Points: | 75.00 | 58.80 | 16.20 |