| 9/5/2020 | Arkansas State | 24 | at | Memphis | 37 | SBC | ||
| SMU | 31 | at | Texas State | 24 | @ SBC | |||
| 9/7/2020 | BYU | 55 | at | Navy | 3 | Ind | ||
| 9/12/2020 | Tulane | 27 | at | South Alabama | 24 | @ SBC | ||
| The Citadel | 6 | at | South Florida | 27 | SoCon (1AA) | |||
| 9/19/2020 | Austin Peay | 20 | at | Cincinnati | 55 | OVC (1AA) | ||
| UCF | 49 | at | Georgia Tech | 21 | @ ACC | |||
| SMU | 65 | at | North Texas | 35 | @ CUSA | |||
| South Florida | 0 | at | Notre Dame | 52 | @ ACC | |||
| Tulsa | 7 | at | Oklahoma State | 16 | @ B12 | |||
| Navy | 27 | at | Tulane | 24 | ||||
| 9/26/2020 | Army | 10 | at | Cincinnati | 24 | Ind | ||
| UCF | 51 | at | East Carolina | 28 | ||||
| Stephen F. Austin | 7 | at | SMU | 50 | SLC (1AA) | |||
| Tulane | 66 | at | Southern Miss | 24 | @ CUSA | |||
| 10/3/2020 | Navy | 7 | at | Air Force | 40 | @ MW | ||
| South Florida | 7 | at | Cincinnati | 28 | ||||
| East Carolina | 29 | at | Georgia State | 49 | @ SBC | |||
| Memphis | 27 | at | SMU | 30 | ||||
| Tulsa | 34 | at | UCF | 26 | ||||
| 10/8/2020 | Tulane | 31 | at | Houston | 49 | |||
| 10/10/2020 | Temple | 29 | at | Navy | 31 | |||
| East Carolina | 44 | at | South Florida | 24 | ||||
| 10/16/2020 | BYU | at | Houston | Ind | ||||
| SMU | at | Tulane | ||||||
| 10/17/2020 | Navy | at | East Carolina | |||||
| UCF | at | Memphis | ||||||
| South Florida | at | Temple | ||||||
| Cincinnati | at | Tulsa | PPD | |||||
| 10/23/2020 | Tulsa | at | South Florida | |||||
| 10/24/2020 | Temple | at | Memphis | |||||
| Houston | at | Navy | ||||||
| Cincinnati | at | SMU | ||||||
| Tulane | at | UCF | ||||||
| 10/30/2020 | East Carolina | at | Tulsa | |||||
| 10/31/2020 | Memphis | at | Cincinnati | |||||
| UCF | at | Houston | ||||||
| Navy | at | SMU | ||||||
| Temple | at | Tulane | ||||||
| 11/5/2020 | SMU | at | Temple | |||||
| 11/7/2020 | Houston | at | Cincinnati | |||||
| Tulane | at | East Carolina | ||||||
| South Florida | at | Memphis | ||||||
| Tulsa | at | Navy | ||||||
| 11/13/2020 | East Carolina | at | Cincinnati | |||||
| 11/14/2020 | South Florida | at | Houston | |||||
| Memphis | at | Navy | ||||||
| Army | at | Tulane | Ind | |||||
| SMU | at | Tulsa | ||||||
| Temple | at | UCF | ||||||
| 11/21/2020 | Stephen F. Austin | at | Memphis | SLC (1AA) | ||||
| Houston | at | SMU | ||||||
| Navy | at | South Florida | ||||||
| East Carolina | at | Temple | ||||||
| Tulane | at | Tulsa | ||||||
| Cincinnati | at | UCF | ||||||
| 11/27/2020 | UCF | at | South Florida | |||||
| 11/28/2020 | SMU | at | East Carolina | |||||
| Tulsa | at | Houston | ||||||
| Cincinnati | at | Temple | ||||||
| Memphis | at | Tulane | ||||||
| 12/5/2020 | Houston | at | Memphis | |||||
| 12/12/2020 | Army | vs | Navy | Philadelphia, PA | vs Ind |