| 9/4/2023 | Clemson (9-4,4-4) | 7 | at | Duke | 28 | |||
| 9/9/2023 | Lafayette (9-3) | 7 | at | Duke | 42 | Pat (1AA) | ||
| 9/16/2023 | Northwestern (8-5) | 14 | at | Duke | 38 | B10 | ||
| 9/23/2023 | Duke | 41 | at | Connecticut (3-9) | 7 | at Ind | ||
| 9/30/2023 | Notre Dame (10-3) | 21 | at | Duke | 14 | ND | ||
| 10/14/2023 | North Carolina State (9-4,6-2) | 3 | at | Duke | 24 | |||
| 10/21/2023 | Duke | 20 | at | Florida State (13-1,9-0) | 38 | |||
| 10/28/2023 | Duke | 0 | at | Louisville (10-4,7-2) | 23 | |||
| 11/2/2023 | Wake Forest (4-8,1-7) | 21 | at | Duke | 24 | |||
| 11/11/2023 | Duke | 45 | at | North Carolina (8-5,4-4) | 47 | 2OT | ||
| 11/18/2023 | Duke | 27 | at | Virginia (3-9,2-6) | 30 | |||
| 11/25/2023 | Pittsburgh (3-9,2-6) | 19 | at | Duke | 30 | |||
| 12/23/2023 | Troy (11-3) | 10 | vs | Duke | 17 | Birmingham Bowl | SBC |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 5-8 | 95-59 | |
| Points Scored: | 19.00 | 28.63 | 9.63 |
| Points Allowed: | 26.92 | 23.08 | 3.84 |
| Margin: | -7.92 | 5.55 | 13.47 |
| Total Points: | 45.92 | 51.71 | -5.79 |