| 9/4/2023 | Clemson | 7 | at | Duke (8-5,4-4) | 28 | |||
| 9/9/2023 | Charleston Southern (4-7) | 17 | at | Clemson | 66 | BigS (1AA) | ||
| 9/16/2023 | Florida Atlantic (4-8) | 14 | at | Clemson | 48 | AAC | ||
| 9/23/2023 | Florida State (13-1,9-0) | 31 | at | Clemson | 24 | OT | ||
| 9/30/2023 | Clemson | 31 | at | Syracuse (6-7,2-6) | 14 | |||
| 10/7/2023 | Wake Forest (4-8,1-7) | 12 | at | Clemson | 17 | |||
| 10/21/2023 | Clemson | 20 | at | Miami-Florida (7-6,3-5) | 28 | 2OT | ||
| 10/28/2023 | Clemson | 17 | at | North Carolina State (9-4,6-2) | 24 | |||
| 11/4/2023 | Notre Dame (10-3) | 23 | at | Clemson | 31 | ND | ||
| 11/11/2023 | Georgia Tech (7-6,5-3) | 21 | at | Clemson | 42 | |||
| 11/18/2023 | North Carolina (8-5,4-4) | 20 | at | Clemson | 31 | |||
| 11/25/2023 | Clemson | 16 | at | South Carolina (5-7) | 7 | at SEC | ||
| 12/29/2023 | Clemson | 38 | vs | Kentucky (7-6) | 35 | Gator Bowl - Jacksonville FL | vs SEC |
| vs Clemson | vs Other Opponents | Clemson compared to OOs | |
| Record: | 4-9 | 88-64 | |
| Points Scored: | 21.08 | 28.76 | 7.68 |
| Points Allowed: | 29.85 | 23.52 | 6.33 |
| Margin: | -8.77 | 5.24 | 14.01 |
| Total Points: | 50.93 | 52.28 | -1.35 |