| 9/3/2022 | Winona State | 24 | at | Minot State (1-10,1-10) | 10 | | | |
| 9/10/2022 | Mary (2-9,2-9) | 17 | at | Winona State | 25 | | | |
| 9/17/2022 | Winona State | 24 | at | Bemidji State (10-3,10-2) | 34 | | | |
| 9/24/2022 | Minnesota State-Moorhead (4-7,4-7) | 7 | at | Winona State | 40 | | | |
| 10/1/2022 | Wayne State NE (9-3,9-3) | 14 | at | Winona State | 38 | | | |
| 10/8/2022 | Winona State | 21 | at | Northern State (6-5,6-5) | 42 | | | |
| 10/15/2022 | Winona State | 43 | at | Southwest Minnesota State (4-7,4-7) | 7 | | | |
| 10/22/2022 | Sioux Falls (8-3,8-3) | 17 | at | Winona State | 20 | | | |
| 10/29/2022 | Augustana SD (7-4,7-4) | 7 | at | Winona State | 24 | | | |
| 11/5/2022 | Winona State | 45 | at | Upper Iowa (1-10,1-10) | 7 | | | |
| 11/12/2022 | Winona State | 13 | at | Minnesota State-Mankato (10-3,10-2) | 40 | | | |
| 11/19/2022 | Winona State | 7 | at | Bemidji State (10-3,10-2) | 31 | | D2 Championship Round 1 | |