| 9/1/2022 | Southwest Minnesota State | 21 | at | Minnesota-Duluth (8-3,8-3) | 31 | | | |
| 9/10/2022 | Concordia-St Paul (1-10,1-10) | 6 | at | Southwest Minnesota State | 14 | | | |
| 9/17/2022 | Southwest Minnesota State | 31 | at | Mary (2-9,2-9) | 28 | | | |
| 9/24/2022 | Minot State (1-10,1-10) | 20 | at | Southwest Minnesota State | 27 | OT | | |
| 10/1/2022 | Upper Iowa (1-10,1-10) | 7 | at | Southwest Minnesota State | 47 | | | |
| 10/8/2022 | Southwest Minnesota State | 14 | at | Sioux Falls (8-3,8-3) | 35 | | | |
| 10/15/2022 | Winona State (8-4,8-4) | 43 | at | Southwest Minnesota State | 7 | | | |
| 10/22/2022 | Southwest Minnesota State | 14 | at | Wayne State NE (9-3,9-3) | 20 | | | |
| 10/29/2022 | Bemidji State (10-3,10-2) | 34 | at | Southwest Minnesota State | 15 | | | |
| 11/5/2022 | Southwest Minnesota State | 24 | at | Minnesota State-Mankato (10-3,10-2) | 45 | | | |
| 11/12/2022 | Augustana SD (7-4,7-4) | 49 | at | Southwest Minnesota State | 0 | | | |