9/1/2022 | Minnesota State-Mankato | 37 | at | Bemidji State | 34 | | | |
| Augustana SD | 28 | at | Concordia-St Paul | 14 | | | |
| Sioux Falls | 27 | at | Minnesota State-Moorhead | 14 | | | |
| Southwest Minnesota State | 21 | at | Minnesota-Duluth | 31 | | | |
| Upper Iowa | 0 | at | Northern State | 30 | | | |
9/3/2022 | Wayne State NE | 33 | at | Mary | 28 | | | |
| Winona State | 24 | at | Minot State | 10 | | | |
9/10/2022 | Bemidji State | 29 | at | Augustana SD | 30 | | | |
| Minnesota-Duluth | 10 | at | Minnesota State-Mankato | 17 | | | |
| Minot State | 0 | at | Sioux Falls | 34 | | | |
| Concordia-St Paul | 6 | at | Southwest Minnesota State | 14 | | | |
| Minnesota State-Moorhead | 24 | at | Upper Iowa | 21 | | | |
| Northern State | 6 | at | Wayne State NE | 13 | | | |
| Mary | 17 | at | Winona State | 25 | | | |
9/17/2022 | Winona State | 24 | at | Bemidji State | 34 | | | |
| Sioux Falls | 44 | at | Concordia-St Paul | 23 | | | |
| Southwest Minnesota State | 31 | at | Mary | 28 | | | |
| Augustana SD | 31 | at | Minnesota State-Moorhead | 7 | | | |
| Upper Iowa | 6 | at | Minnesota-Duluth | 28 | | | |
| Wayne State NE | 49 | at | Minot State | 10 | | | |
| Minnesota State-Mankato | 22 | at | Northern State | 23 | | | |
9/24/2022 | Northern State | 13 | at | Augustana SD | 21 | | | |
| Mary | 28 | at | Minnesota State-Mankato | 31 | | | |
| Minnesota-Duluth | 31 | at | Sioux Falls | 34 | | | |
| Minot State | 20 | at | Southwest Minnesota State | 27 | OT | | |
| Bemidji State | 48 | at | Upper Iowa | 22 | | | |
| Concordia-St Paul | 21 | at | Wayne State NE | 48 | | | |
| Minnesota State-Moorhead | 7 | at | Winona State | 40 | | | |
10/1/2022 | Sioux Falls | 31 | at | Augustana SD | 24 | | | |
| Minnesota State-Mankato | 25 | at | Concordia-St Paul | 15 | | | |
| Northern State | 26 | at | Mary | 27 | OT | | |
| Minnesota State-Moorhead | 28 | at | Minnesota-Duluth | 36 | | | |
| Bemidji State | 59 | at | Minot State | 14 | | | |
| Upper Iowa | 7 | at | Southwest Minnesota State | 47 | | | |
| Wayne State NE | 14 | at | Winona State | 38 | | | |
10/8/2022 | Concordia-St Paul | 0 | at | Bemidji State | 44 | | | |
| Minot State | 14 | at | Minnesota State-Moorhead | 36 | | | |
| Mary | 14 | at | Minnesota-Duluth | 49 | | | |
| Winona State | 21 | at | Northern State | 42 | | | |
| Southwest Minnesota State | 14 | at | Sioux Falls | 35 | | | |
| Augustana SD | 31 | at | Upper Iowa | 14 | | | |
| Minnesota State-Mankato | 33 | at | Wayne State NE | 41 | | | |
10/15/2022 | Wayne State NE | 27 | at | Augustana SD | 31 | | | |
| Minnesota-Duluth | 53 | at | Concordia-St Paul | 7 | | | |
| Sioux Falls | 41 | at | Mary | 27 | | | |
| Upper Iowa | 20 | at | Minnesota State-Mankato | 43 | | | |
| Bemidji State | 46 | at | Minnesota State-Moorhead | 7 | | | |
| Northern State | 38 | at | Minot State | 10 | | | |
| Winona State | 43 | at | Southwest Minnesota State | 7 | | | |
10/22/2022 | Minnesota State-Mankato | 35 | at | Augustana SD | 14 | | | |
| Minnesota-Duluth | 16 | at | Bemidji State | 41 | | | |
| Minnesota State-Moorhead | 40 | at | Mary | 38 | | | |
| Concordia-St Paul | 20 | at | Northern State | 49 | | | |
| Minot State | 22 | at | Upper Iowa | 33 | | | |
| Southwest Minnesota State | 14 | at | Wayne State NE | 20 | | | |
| Sioux Falls | 17 | at | Winona State | 20 | | | |
10/29/2022 | Mary | 23 | at | Concordia-St Paul | 13 | | | |
| Minot State | 7 | at | Minnesota-Duluth | 51 | | | |
| Minnesota State-Moorhead | 7 | at | Northern State | 35 | | | |
| Minnesota State-Mankato | 38 | at | Sioux Falls | 24 | | | |
| Bemidji State | 34 | at | Southwest Minnesota State | 15 | | | |
| Upper Iowa | 14 | at | Wayne State NE | 56 | | | |
| Augustana SD | 7 | at | Winona State | 24 | | | |
11/5/2022 | Minnesota-Duluth | 34 | at | Augustana SD | 24 | | | |
| Northern State | 14 | at | Bemidji State | 24 | | | |
| Southwest Minnesota State | 24 | at | Minnesota State-Mankato | 45 | | | |
| Concordia-St Paul | 20 | at | Minnesota State-Moorhead | 21 | | | |
| Mary | 10 | at | Minot State | 17 | | | |
| Wayne State NE | 31 | at | Sioux Falls | 24 | | | |
| Winona State | 45 | at | Upper Iowa | 7 | | | |
11/12/2022 | Minot State | 11 | at | Concordia-St Paul | 19 | | | |
| Bemidji State | 51 | at | Mary | 14 | | | |
| Winona State | 13 | at | Minnesota State-Mankato | 40 | | | |
| Minnesota-Duluth | 28 | at | Northern State | 7 | | | |
| Augustana SD | 49 | at | Southwest Minnesota State | 0 | | | |
| Sioux Falls | 50 | at | Upper Iowa | 6 | | | |
| Minnesota State-Moorhead | 7 | at | Wayne State NE | 10 | | | |
11/19/2022 | Winona State | 7 | at | Bemidji State | 31 | | D2 Championship Round 1 | |
| Wayne State NE | 9 | at | Minnesota State-Mankato | 26 | | D2 Championship Round 1 | |
11/26/2022 | Bemidji State | 7 | at | Angelo State | 33 | | D2 Playoffs Round 2 | @ LSC |
| Minnesota State-Mankato | 45 | at | Colorado Mines | 48 | | D2 Playoffs Round 2 | @ RMAC |