| 9/1/2022 | Upper Iowa (1-10,1-10) | 0 | at | Northern State | 30 | | | |
| 9/10/2022 | Northern State | 6 | at | Wayne State NE (9-3,9-3) | 13 | | | |
| 9/17/2022 | Minnesota State-Mankato (10-3,10-2) | 22 | at | Northern State | 23 | | | |
| 9/24/2022 | Northern State | 13 | at | Augustana SD (7-4,7-4) | 21 | | | |
| 10/1/2022 | Northern State | 26 | at | Mary (2-9,2-9) | 27 | OT | | |
| 10/8/2022 | Winona State (8-4,8-4) | 21 | at | Northern State | 42 | | | |
| 10/15/2022 | Northern State | 38 | at | Minot State (1-10,1-10) | 10 | | | |
| 10/22/2022 | Concordia-St Paul (1-10,1-10) | 20 | at | Northern State | 49 | | | |
| 10/29/2022 | Minnesota State-Moorhead (4-7,4-7) | 7 | at | Northern State | 35 | | | |
| 11/5/2022 | Northern State | 14 | at | Bemidji State (10-3,10-2) | 24 | | | |
| 11/12/2022 | Minnesota-Duluth (8-3,8-3) | 28 | at | Northern State | 7 | | | |