| 9/1/2022 | Southwest Minnesota State (4-7,4-7) | 21 | at | Minnesota-Duluth | 31 | | | |
| 9/10/2022 | Minnesota-Duluth | 10 | at | Minnesota State-Mankato (10-3,10-2) | 17 | | | |
| 9/17/2022 | Upper Iowa (1-10,1-10) | 6 | at | Minnesota-Duluth | 28 | | | |
| 9/24/2022 | Minnesota-Duluth | 31 | at | Sioux Falls (8-3,8-3) | 34 | | | |
| 10/1/2022 | Minnesota State-Moorhead (4-7,4-7) | 28 | at | Minnesota-Duluth | 36 | | | |
| 10/8/2022 | Mary (2-9,2-9) | 14 | at | Minnesota-Duluth | 49 | | | |
| 10/15/2022 | Minnesota-Duluth | 53 | at | Concordia-St Paul (1-10,1-10) | 7 | | | |
| 10/22/2022 | Minnesota-Duluth | 16 | at | Bemidji State (10-3,10-2) | 41 | | | |
| 10/29/2022 | Minot State (1-10,1-10) | 7 | at | Minnesota-Duluth | 51 | | | |
| 11/5/2022 | Minnesota-Duluth | 34 | at | Augustana SD (7-4,7-4) | 24 | | | |
| 11/12/2022 | Minnesota-Duluth | 28 | at | Northern State (6-5,6-5) | 7 | | | |