| 9/4/2021 | Pikeville | at | St Thomas FL (8-2,7-2) | 1 | Forfeit | |||
| 9/18/2021 | Bluefield (6-5,5-5) | 20 | at | Pikeville | 52 | |||
| 9/25/2021 | Webber International (2-8,2-8) | 0 | at | Pikeville | 59 | |||
| 10/2/2021 | Pikeville | 14 | at | Georgetown KY (8-2,8-2) | 52 | |||
| 10/9/2021 | Pikeville | 28 | at | Campbellsville (1-9,1-9) | 31 | |||
| 10/16/2021 | Bethel TN (7-4,7-3) | 44 | at | Pikeville | 13 | |||
| 10/23/2021 | Lindsey Wilson (12-1,11-0) | 31 | at | Pikeville | 0 | |||
| 10/30/2021 | Cumberlands KY (6-4,6-4) | 41 | at | Pikeville | 38 | |||
| 11/6/2021 | Pikeville | 14 | at | Cumberland TN (3-7,3-7) | 9 | |||
| 11/13/2021 | Pikeville | 13 | at | Thomas More (5-5,5-5) | 7 |
| vs Pikeville | vs Other Opponents | Pikeville compared to OOs | |
| Record: | 5-4 | 53-43 | |
| Points Scored: | 26.11 | 31.05 | 4.94 |
| Points Allowed: | 25.67 | 26.63 | -0.96 |
| Margin: | 0.44 | 4.42 | 3.98 |
| Total Points: | 51.78 | 57.68 | -5.90 |