| 9/2/2021 | California PA (9-1) | 23 | at | Fairmont State | 14 | | | PSAC |
| 9/9/2021 | Fairmont State | 6 | at | Charleston WV (8-2,8-2) | 27 | | | |
| 9/18/2021 | West Virginia State (6-5,6-4) | 30 | at | Fairmont State | 23 | | | |
| 9/25/2021 | Fairmont State | 30 | at | UNC Pembroke (5-5,5-4) | 27 | | | |
| 10/2/2021 | Concord (4-6,4-6) | 27 | at | Fairmont State | 31 | | | |
| 10/9/2021 | Alderson-Broaddus (1-10,1-9) | 10 | at | Fairmont State | 44 | | | |
| 10/16/2021 | Fairmont State | 31 | at | West Liberty (4-7,4-6) | 52 | | | |
| 10/23/2021 | Frostburg State (10-1,9-1) | 49 | at | Fairmont State | 14 | | | |
| 10/30/2021 | Fairmont State | 0 | at | Notre Dame OH (11-2,9-1) | 45 | | | |
| 11/6/2021 | Fairmont State | 24 | at | Glenville State (3-7,3-7) | 14 | | | |
| 11/12/2021 | Wheeling (5-6,5-5) | 14 | at | Fairmont State | 29 | | | |