| 9/26/2020 | Alabama (13-0,11-0) | 38 | at | Missouri | 19 | |||
| 10/3/2020 | Missouri | 12 | at | Tennessee (3-7,3-7) | 35 | |||
| 10/10/2020 | LSU (5-5,5-5) | 41 | at | Missouri | 45 | |||
| 10/17/2020 | Vanderbilt (0-9,0-9) | at | Missouri | PPD | ||||
| 10/24/2020 | Kentucky (5-6,4-6) | 10 | at | Missouri | 20 | |||
| 10/31/2020 | Missouri | 17 | at | Florida (8-4,8-3) | 41 | |||
| 11/14/2020 | Georgia (8-2,7-2) | at | Missouri | PPD | ||||
| 11/21/2020 | Missouri | 17 | at | South Carolina (2-8,2-8) | 10 | |||
| 11/28/2020 | Vanderbilt (0-9,0-9) | 0 | at | Missouri | 41 | |||
| 12/5/2020 | Arkansas (3-7,3-7) | 48 | at | Missouri | 50 | |||
| 12/12/2020 | Georgia (8-2,7-2) | 49 | at | Missouri | 14 | |||
| 12/19/2020 | Missouri | 32 | at | Mississippi State (4-7,3-7) | 51 | |||
| 12/30/2020 | Iowa (6-2) | vs | Missouri | CCD Music City Bowl | B10 |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 5-5 | 59-62 | |
| Points Scored: | 32.30 | 28.54 | -3.76 |
| Points Allowed: | 26.70 | 28.99 | -2.29 |
| Margin: | 5.60 | -0.45 | -6.05 |
| Total Points: | 59.00 | 57.53 | 1.47 |