| 8/31/2019 | Alcorn State (9-4) | 10 | at | Southern Miss | 38 | SWAC (1AA) | ||
| 9/7/2019 | Southern Miss | 15 | at | Mississippi State (6-7) | 38 | at SEC | ||
| 9/14/2019 | Southern Miss | 47 | at | Troy (5-7) | 42 | at SBC | ||
| 9/21/2019 | Southern Miss | 7 | at | Alabama (11-2) | 49 | at SEC | ||
| 9/28/2019 | UTEP (1-11,0-8) | 13 | at | Southern Miss | 31 | |||
| 10/12/2019 | North Texas (4-8,3-5) | 27 | at | Southern Miss | 45 | |||
| 10/19/2019 | Southern Miss | 30 | at | Louisiana Tech (10-3,6-2) | 45 | |||
| 10/26/2019 | Southern Miss | 20 | at | Rice (3-9,3-5) | 6 | |||
| 11/9/2019 | UAB (9-5,6-3) | 2 | at | Southern Miss | 37 | |||
| 11/16/2019 | Southern Miss | 36 | at | Texas-San Antonio (4-8,3-5) | 17 | |||
| 11/23/2019 | Western Kentucky (9-4,6-2) | 28 | at | Southern Miss | 10 | |||
| 11/30/2019 | Southern Miss | 17 | at | Florida Atlantic (11-3,8-1) | 34 | |||
| 1/4/2020 | Southern Miss | 13 | vs | Tulane (7-6) | 30 | Armed Forces Bowl - Fort Worth TX | vs AAC |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 6-7 | 83-70 | |
| Points Scored: | 26.23 | 29.75 | 3.52 |
| Points Allowed: | 26.62 | 26.37 | 0.25 |
| Margin: | -0.39 | 3.38 | 3.77 |
| Total Points: | 52.85 | 56.12 | -3.27 |