| 8/30/2019 | Oklahoma State | 52 | at | Oregon State (5-7) | 36 | at P12 | ||
| 9/7/2019 | McNeese State (7-5) | 14 | at | Oklahoma State | 56 | SLC (1AA) | ||
| 9/14/2019 | Oklahoma State | 40 | at | Tulsa (4-8) | 21 | at AAC | ||
| 9/21/2019 | Oklahoma State | 30 | at | Texas (8-5,5-4) | 36 | |||
| 9/28/2019 | Kansas State (8-5,5-4) | 13 | at | Oklahoma State | 26 | |||
| 10/5/2019 | Oklahoma State | 35 | at | Texas Tech (4-8,2-7) | 45 | |||
| 10/19/2019 | Baylor (11-3,8-2) | 45 | at | Oklahoma State | 27 | |||
| 10/26/2019 | Oklahoma State | 34 | at | Iowa State (7-6,5-4) | 27 | |||
| 11/2/2019 | TCU (5-7,3-6) | 27 | at | Oklahoma State | 34 | |||
| 11/16/2019 | Kansas (3-9,1-8) | 13 | at | Oklahoma State | 31 | |||
| 11/23/2019 | Oklahoma State | 20 | at | West Virginia (5-7,3-6) | 13 | |||
| 11/30/2019 | Oklahoma (12-2,9-1) | 34 | at | Oklahoma State | 16 | |||
| 12/27/2019 | Oklahoma State | 21 | vs | Texas A&M (8-5) | 24 | Texas Bowl - Houston TX | vs SEC |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 5-8 | 82-69 | |
| Points Scored: | 26.77 | 30.60 | 3.83 |
| Points Allowed: | 32.46 | 26.75 | 5.71 |
| Margin: | -5.69 | 3.85 | 9.54 |
| Total Points: | 59.23 | 57.35 | 1.88 |