| 8/23/2018 | Southwestern Assemblies of God | 9 | at | Evangel | 28 | | | @ HAAC |
| 8/25/2018 | Lyon | 22 | at | Missouri Baptist | 9 | | | @ MSFA |
| 9/1/2018 | Sul Ross State | 20 | at | Arizona Christian | 42 | | | ASWC (D3) |
| Southwestern Assemblies of God | 37 | at | Austin | 28 | | | @ SAA (D3) |
| Lyon | 27 | at | Hendrix | 37 | | | @ SAA (D3) |
| Hastings | 26 | at | Panhandle State | 17 | | | GPAC |
| Kansas Wesleyan | 42 | at | Texas Wesleyan | 7 | | | KCAC |
| 9/8/2018 | Whittier | 42 | at | Arizona Christian | 67 | | | SCIAC (D3) |
| Ottawa AZ | 56 | at | Langston | 63 | | | |
| Texas Wesleyan | 10 | at | Texas A&M-Kingsville | 52 | | | @ LSC (D2) |
| Austin | 14 | at | Wayland Baptist | 24 | | | SAA (D3) |
| Panhandle State | 7 | at | West Texas A&M | 42 | | | @ LSC (D2) |
| 9/15/2018 | Arizona Christian | 26 | at | Lyon | 23 | OT | | |
| Panhandle State | 38 | at | Ottawa AZ | 35 | | | |
| Langston | 18 | at | Southern | 33 | | | @ SWAC (1AA) |
| Texas College | 7 | at | Texas Wesleyan | 36 | | | |
| Southwestern Assemblies of God | 54 | at | Wayland Baptist | 23 | | | |
| 9/22/2018 | Texas Wesleyan | 29 | at | Arizona Christian | 36 | | | |
| Southwestern Assemblies of God | 20 | at | Langston | 35 | | | |
| Wayland Baptist | 17 | at | Panhandle State | 20 | | | |
| Lyon | 11 | at | Ottawa AZ | 51 | | | |
| 9/29/2018 | Wayland Baptist | 20 | at | Langston | 31 | | | |
| Panhandle State | 16 | at | Lyon | 29 | | | |
| Ottawa AZ | 34 | at | Southwestern Assemblies of God | 56 | | | |
| Arizona Christian | 31 | at | Texas College | 27 | | | |
| 10/6/2018 | Panhandle State | 7 | at | Grambling | 62 | | | @ SWAC (1AA) |
| Arizona Christian | 28 | at | Ottawa AZ | 73 | | | |
| Texas College | 28 | at | Southwestern Assemblies of God | 48 | | | |
| Langston | 55 | at | Texas Wesleyan | 31 | | | |
| Lyon | 43 | at | Wayland Baptist | 49 | 4OT | | |
| 10/13/2018 | Langston | 38 | at | Arizona Christian | 17 | | | |
| Southwestern Assemblies of God | 34 | at | Lyon | 37 | | | |
| Texas College | 14 | at | Ottawa AZ | 63 | | | |
| Panhandle State | 49 | at | Texas Wesleyan | 25 | | | |
| 10/20/2018 | Lyon | 21 | at | Langston | 48 | | | |
| Arizona Christian | 14 | at | Panhandle State | 21 | | | |
| Texas Wesleyan | 46 | at | Southwestern Assemblies of God | 53 | | | |
| Wayland Baptist | 32 | at | Texas College | 28 | | | |
| 10/27/2018 | Panhandle State | 35 | at | Southwestern Assemblies of God | 20 | | | |
| Langston | 71 | at | Texas College | 48 | | | |
| Texas Wesleyan | 30 | at | Wayland Baptist | 41 | | | |
| 11/3/2018 | Southwestern Assemblies of God | 30 | at | Arizona Christian | 34 | | | |
| Texas College | 0 | at | Panhandle State | 42 | | | |
| Wayland Baptist | 14 | at | Ottawa AZ | 75 | | | |
| Lyon | 20 | at | Texas Wesleyan | 21 | | | |
| 11/10/2018 | Panhandle State | 9 | at | Langston | 33 | | | |
| Texas College | 38 | at | Lyon | 37 | | | |
| Ottawa AZ | 35 | at | Texas Wesleyan | 29 | | | |
| Arizona Christian | 37 | at | Wayland Baptist | 36 | | | |
| 11/17/2018 | Langston | 9 | at | Kansas Wesleyan | 15 | | NAIA Playoff Round 1 | @ KCAC |
| 11/30/2018 | Olivet Nazarene | 38 | at | Ottawa AZ | 35 | | NCCAAVictory Bowl | MSFA |