| 8/25/2018 | Lyon | 22 | at | Missouri Baptist (4-7) | 9 | at MSFA | ||
| 9/1/2018 | Lyon | 27 | at | Hendrix (2-8) | 37 | at SAA | ||
| 9/15/2018 | Arizona Christian (7-3,5-3) | 26 | at | Lyon | 23 | OT | ||
| 9/22/2018 | Lyon | 11 | at | Ottawa AZ (5-4,5-3) | 51 | |||
| 9/29/2018 | Panhandle State (6-5,6-2) | 16 | at | Lyon | 29 | |||
| 10/6/2018 | Lyon | 43 | at | Wayland Baptist (4-5,3-5) | 49 | 4OT | ||
| 10/13/2018 | Southwestern Assemblies of God (5-5,4-4) | 34 | at | Lyon | 37 | |||
| 10/20/2018 | Lyon | 21 | at | Langston (8-2,8-0) | 48 | |||
| 11/3/2018 | Lyon | 20 | at | Texas Wesleyan (2-8,2-6) | 21 | |||
| 11/10/2018 | Texas College (1-7,1-7) | 38 | at | Lyon | 37 |
| vs Lyon | vs Other Opponents | Lyon compared to OOs | |
| Record: | 7-3 | 37-51 | |
| Points Scored: | 32.90 | 29.82 | -3.08 |
| Points Allowed: | 27.00 | 33.66 | -6.66 |
| Margin: | 5.90 | -3.84 | -9.74 |
| Total Points: | 59.90 | 63.48 | -3.58 |