| 9/1/2018 | Hanover (7-4) | 18 | at | Centre | 28 | HCA | ||
| 9/8/2018 | Centre | 40 | at | Maryville (7-3) | 6 | at USASC | ||
| 9/15/2018 | Centre | 45 | at | Hendrix (2-8,1-7) | 6 | |||
| 9/22/2018 | Berry (10-2,7-1) | 38 | at | Centre | 35 | OT | ||
| 10/6/2018 | Centre | 38 | at | Austin (2-8,2-6) | 20 | |||
| 10/13/2018 | Trinity TX (7-3,6-2) | 28 | at | Centre | 33 | |||
| 10/20/2018 | Centre | 41 | at | Rhodes (5-5,3-5) | 14 | |||
| 10/27/2018 | Millsaps (5-5,3-5) | 13 | at | Centre | 49 | |||
| 11/3/2018 | Sewanee (4-6,3-5) | 20 | at | Centre | 49 | |||
| 11/10/2018 | Centre | 56 | at | Birmingham-Southern (6-4,4-4) | 20 | |||
| 11/17/2018 | Washington & Jefferson (9-2) | 13 | at | Centre | 54 | D3 Playooff Round 1 | TPAC | |
| 11/24/2018 | Centre | 35 | at | Mount Union (14-1) | 51 | at OAC |
| vs Centre | vs Other Opponents | Centre compared to OOs | |
| Record: | 2-10 | 76-41 | |
| Points Scored: | 20.58 | 29.79 | 9.21 |
| Points Allowed: | 41.92 | 20.02 | 21.90 |
| Margin: | -21.34 | 9.77 | 31.11 |
| Total Points: | 62.50 | 49.81 | 12.69 |