| 8/30/2018 | Millsaps | 18 | at | Belhaven | 3 | @ ASWC | ||
| LaGrange | 28 | at | Birmingham-Southern | 34 | USASC | |||
| Trinity TX | 44 | at | McMurry | 0 | @ ASWC | |||
| 9/1/2018 | Southwestern Assemblies of God | 37 | at | Austin | 28 | Soon (NAIA) | ||
| Maryville | 3 | at | Berry | 38 | USASC | |||
| Hanover | 18 | at | Centre | 28 | HCA | |||
| Lyon | 27 | at | Hendrix | 37 | Soon (NAIA) | |||
| Sewanee | 43 | at | Kenyon | 10 | @ NCA | |||
| Illinois College | 0 | at | Rhodes | 21 | MidW | |||
| 9/8/2018 | Birmingham-Southern | 41 | at | Huntingdon AL | 35 | @ USASC | ||
| Berry | 34 | at | LaGrange | 21 | @ USASC | |||
| Centre | 40 | at | Maryville | 6 | @ USASC | |||
| Westminster MO | 0 | at | Millsaps | 35 | UMWAC | |||
| Rhodes | 43 | at | Rose-Hulman | 19 | @ HCA | |||
| Washington and Lee | 47 | at | Sewanee | 14 | ODC | |||
| Hendrix | 14 | at | Texas Lutheran | 19 | @ ASWC | |||
| Hardin-Simmons | 42 | at | Trinity TX | 33 | ASWC | |||
| Austin | 14 | at | Wayland Baptist | 24 | @ Soon (NAIA) | |||
| 9/15/2018 | Centre | 45 | at | Hendrix | 6 | |||
| Berry | 42 | at | Rhodes | 35 | ||||
| Austin | 20 | at | Sewanee | 28 | ||||
| Millsaps | 10 | at | Trinity TX | 7 | ||||
| 9/22/2018 | Hendrix | 9 | at | Austin | 12 | |||
| Rhodes | 29 | at | Birmingham-Southern | 10 | ||||
| Berry | 38 | at | Centre | 35 | OT | |||
| Millsaps | 21 | at | Sewanee | 14 | ||||
| 9/29/2018 | Austin | 0 | at | Berry | 61 | |||
| Sewanee | 38 | at | Hendrix | 31 | ||||
| Rhodes | 24 | at | Millsaps | 21 | ||||
| Birmingham-Southern | 17 | at | Trinity TX | 24 | ||||
| 10/6/2018 | Centre | 38 | at | Austin | 20 | |||
| Sewanee | 3 | at | Berry | 44 | ||||
| Hendrix | 41 | at | Birmingham-Southern | 57 | ||||
| Trinity TX | 24 | at | Rhodes | 7 | ||||
| 10/13/2018 | Trinity TX | 28 | at | Centre | 33 | |||
| Berry | 35 | at | Hendrix | 14 | ||||
| Austin | 34 | at | Millsaps | 23 | ||||
| Birmingham-Southern | 13 | at | Sewanee | 10 | ||||
| 10/20/2018 | Millsaps | 21 | at | Berry | 28 | OT | ||
| Austin | 35 | at | Birmingham-Southern | 47 | ||||
| Centre | 41 | at | Rhodes | 14 | ||||
| Sewanee | 14 | at | Trinity TX | 28 | ||||
| 10/27/2018 | Birmingham-Southern | 10 | at | Berry | 26 | |||
| Millsaps | 13 | at | Centre | 49 | ||||
| Trinity TX | 38 | at | Hendrix | 14 | ||||
| Rhodes | 14 | at | Sewanee | 27 | ||||
| 11/3/2018 | Trinity TX | 14 | at | Austin | 0 | |||
| Sewanee | 20 | at | Centre | 49 | ||||
| Birmingham-Southern | 34 | at | Millsaps | 17 | ||||
| Hendrix | 30 | at | Rhodes | 20 | ||||
| 11/10/2018 | Rhodes | 21 | at | Austin | 14 | |||
| Centre | 56 | at | Birmingham-Southern | 20 | ||||
| Hendrix | 21 | at | Millsaps | 28 | ||||
| Berry | 17 | at | Trinity TX | 21 | ||||
| 11/17/2018 | Maryville | 0 | at | Berry | 31 | D3 Playooff Round 1 | USASC | |
| Washington & Jefferson | 13 | at | Centre | 54 | D3 Playooff Round 1 | TPAC | ||
| 11/24/2018 | Berry | 9 | at | Mary Hardin-Baylor | 75 | @ ASWC | ||
| Centre | 35 | at | Mount Union | 51 | @ OAC |