| 8/30/2018 | Central Oklahoma (8-4,7-4) | 7 | at | Pittsburg State | 21 | | | |
| 9/6/2018 | Pittsburg State | 34 | at | Emporia State (8-4,7-4) | 13 | | | |
| 9/15/2018 | Pittsburg State | 45 | at | Northeastern State (0-11,0-11) | 7 | | | |
| 9/22/2018 | Nebraska-Kearney (5-6,5-6) | 17 | at | Pittsburg State | 30 | | | |
| 9/29/2018 | Pittsburg State | 27 | at | Lindenwood (4-7,4-7) | 24 | OT | | |
| 10/6/2018 | Northwest Missouri State (10-3,9-2) | 31 | at | Pittsburg State | 7 | | | |
| 10/13/2018 | Pittsburg State | 21 | at | Fort Hays State (9-3,9-2) | 50 | | | |
| 10/20/2018 | Central Missouri (5-6,5-6) | 28 | at | Pittsburg State | 48 | | | |
| 10/27/2018 | Pittsburg State | 34 | at | Missouri Western (7-5,6-5) | 14 | | | |
| 11/3/2018 | Washburn (5-6,5-6) | 40 | at | Pittsburg State | 23 | | | |
| 11/10/2018 | Pittsburg State | 41 | at | Missouri Southern (1-10,1-10) | 0 | | | |