| 8/30/2018 | Missouri Western (7-5,6-5) | 6 | at | Northwest Missouri State | 28 | | | |
| 9/6/2018 | Northwest Missouri State | 38 | at | Washburn (5-6,5-6) | 17 | | | |
| 9/15/2018 | Missouri Southern (1-10,1-10) | 0 | at | Northwest Missouri State | 63 | | | |
| 9/22/2018 | Northwest Missouri State | 21 | at | Central Oklahoma (8-4,7-4) | 31 | | | |
| 9/29/2018 | Emporia State (8-4,7-4) | 0 | at | Northwest Missouri State | 41 | | | |
| 10/6/2018 | Northwest Missouri State | 31 | at | Pittsburg State (8-3,8-3) | 7 | | | |
| 10/13/2018 | Nebraska-Kearney (5-6,5-6) | 13 | at | Northwest Missouri State | 27 | | | |
| 10/20/2018 | Northwest Missouri State | 38 | at | Lindenwood (4-7,4-7) | 17 | | | |
| 10/27/2018 | Northwest Missouri State | 62 | at | Northeastern State (0-11,0-11) | 17 | | | |
| 11/3/2018 | Fort Hays State (9-3,9-2) | 17 | at | Northwest Missouri State | 16 | | | |
| 11/10/2018 | Northwest Missouri State | 48 | at | Central Missouri (5-6,5-6) | 21 | | | |
| 11/17/2018 | Northwest Missouri State | 42 | at | Grand Valley State (10-2) | 17 | | D2 Playoff Round 1 | at GLIAC |
| 11/24/2018 | Northwest Missouri State | 21 | at | Ferris State (15-1) | 27 | | | at GLIAC |