| 8/30/2018 | Missouri Southern | 0 | at | Nebraska-Kearney (5-6,5-6) | 45 | | | |
| 9/8/2018 | Lindenwood (4-7,4-7) | 51 | at | Missouri Southern | 13 | | | |
| 9/15/2018 | Missouri Southern | 0 | at | Northwest Missouri State (10-3,9-2) | 63 | | | |
| 9/22/2018 | Fort Hays State (9-3,9-2) | 55 | at | Missouri Southern | 20 | | | |
| 9/29/2018 | Missouri Southern | 7 | at | Central Missouri (5-6,5-6) | 61 | | | |
| 10/6/2018 | Missouri Western (7-5,6-5) | 33 | at | Missouri Southern | 10 | | | |
| 10/13/2018 | Missouri Southern | 7 | at | Washburn (5-6,5-6) | 63 | | | |
| 10/20/2018 | Northeastern State (0-11,0-11) | 19 | at | Missouri Southern | 24 | | | |
| 10/27/2018 | Central Oklahoma (8-4,7-4) | 31 | at | Missouri Southern | 0 | | | |
| 11/3/2018 | Missouri Southern | 0 | at | Emporia State (8-4,7-4) | 48 | | | |
| 11/10/2018 | Pittsburg State (8-3,8-3) | 41 | at | Missouri Southern | 0 | | | |