| 8/30/2018 | California PA | 23 | at | Ohio Dominican | 28 | PSAC | ||
| Alderson-Broaddus | 7 | at | Saginaw Valley State | 45 | @ GLIAC | |||
| Walsh | 0 | at | Wayne State MI | 31 | @ GLIAC | |||
| 9/1/2018 | Mercyhurst | 9 | at | Hillsdale | 14 | PSAC | ||
| Findlay | 69 | at | Kentucky Wesleyan | 19 | ||||
| Edinboro | 69 | at | Lake Erie | 0 | PSAC | |||
| Concordia MI | 42 | at | Malone | 27 | MSFA (NAIA) | |||
| 9/8/2018 | Bowie State | 38 | at | Alderson-Broaddus | 31 | CIAA | ||
| Findlay | 13 | at | Ferris State | 59 | @ GLIAC | |||
| Lake Erie | 12 | at | Malone | 42 | ||||
| Hillsdale | 30 | at | Michigan Tech | 31 | OT | @ GLIAC | ||
| Ashland | 17 | at | Ohio Dominican | 24 | GLIAC | |||
| Kentucky Wesleyan | 24 | at | Quincy | 31 | @ GLV | |||
| Saginaw Valley State | 41 | at | Walsh | 10 | GLIAC | |||
| 9/13/2018 | Lake Erie | 19 | at | Urbana | 27 | @ MtnE | ||
| 9/15/2018 | Tiffin | 29 | at | Alderson-Broaddus | 24 | GLIAC | ||
| William Jewell | 17 | at | Findlay | 58 | GLV | |||
| Walsh | at | Jacksonville | CCD | @ Pio (1AA) | ||||
| Kentucky State | 13 | at | Kentucky Wesleyan | 19 | SIAC | |||
| Hillsdale | 34 | at | Ohio Dominican | 18 | ||||
| 9/22/2018 | Ohio Dominican | 34 | at | Findlay | 21 | |||
| Alderson-Broaddus | 45 | at | Glenville State | 17 | @ MtnE | |||
| Lake Erie | 7 | at | Hillsdale | 41 | ||||
| Malone | 38 | at | Kentucky Wesleyan | 44 | ||||
| Tiffin | 27 | at | Walsh | 20 | GLIAC | |||
| 9/29/2018 | Walsh | 23 | at | Kentucky Wesleyan | 17 | |||
| Findlay | 70 | at | Lake Erie | 7 | ||||
| Hillsdale | 45 | at | Malone | 35 | ||||
| Alderson-Broaddus | 27 | at | Ohio Dominican | 66 | ||||
| 10/6/2018 | Lake Erie | 27 | at | Alderson-Broaddus | 55 | |||
| Hillsdale | 20 | at | Findlay | 17 | ||||
| Malone | 21 | at | Tiffin | 38 | @ GLIAC | |||
| Ohio Dominican | 20 | at | Walsh | 10 | ||||
| 10/13/2018 | Findlay | 35 | at | Charleston WV | 24 | @ MtnE | ||
| Alderson-Broaddus | 24 | at | Hillsdale | 45 | ||||
| Walsh | 29 | at | Lake Erie | 0 | ||||
| Malone | 17 | at | Ohio Dominican | 57 | ||||
| Kentucky Wesleyan | 17 | at | Tiffin | 43 | @ GLIAC | |||
| 10/20/2018 | Findlay | 45 | at | Alderson-Broaddus | 43 | |||
| Lake Erie | 6 | at | Kentucky Wesleyan | 46 | ||||
| Malone | 38 | at | Millersville | 34 | @ PSAC | |||
| Ohio Dominican | 23 | at | Tiffin | 24 | @ GLIAC | |||
| Hillsdale | 28 | at | Walsh | 9 | ||||
| 10/27/2018 | Ohio Dominican | 48 | at | East Stroudsburg | 35 | @ PSAC | ||
| Walsh | 16 | at | Findlay | 24 | ||||
| Kentucky Wesleyan | 0 | at | Hillsdale | 34 | ||||
| Tiffin | 40 | at | Lake Erie | 28 | GLIAC | |||
| Alderson-Broaddus | 60 | at | Malone | 55 | ||||
| 11/3/2018 | Malone | 17 | at | Findlay | 63 | |||
| Tiffin | 26 | at | Hillsdale | 48 | GLIAC | |||
| Kentucky Wesleyan | 7 | at | Ohio Dominican | 65 | ||||
| Lake Erie | 0 | at | Thomas More | 44 | @ D3Ind (D3) | |||
| Alderson-Broaddus | 39 | at | Walsh | 42 | ||||
| 11/10/2018 | Kentucky Wesleyan | 7 | at | Alderson-Broaddus | 51 | |||
| Hillsdale | 24 | at | Indianapolis | 34 | @ GLV | |||
| Ohio Dominican | 62 | at | Lake Erie | 6 | ||||
| Walsh | 27 | at | Malone | 22 | ||||
| Findlay | 38 | at | Tiffin | 16 | @ GLIAC | |||
| 11/17/2018 | Hillsdale | 40 | at | Kutztown | 26 | D2 Playoff Round 1 | @ PSAC | |
| 11/24/2018 | Hillsdale | 14 | at | Notre Dame OH | 19 | @ MtnE |