| 8/30/2018 | LaGrange | 28 | at | Birmingham-Southern | 34 | @ SAA | ||
| 9/1/2018 | Maryville | 3 | at | Berry | 38 | @ SAA | ||
| Brevard | 13 | at | Davidson | 34 | @ Pio (1AA) | |||
| Apprentice | 34 | at | Greensboro | 13 | D3Ind | |||
| Huntingdon AL | at | Guilford | CCD | @ ODC | ||||
| Shenandoah | 48 | at | Methodist | 33 | ODC | |||
| Thomas More | 28 | at | North Carolina Wesleyan | 35 | D3Ind | |||
| 9/2/2018 | Hampden-Sydney | 14 | at | Averett | 33 | ODC | ||
| 9/8/2018 | Gallaudet | 28 | at | Greensboro | 44 | ECFC | ||
| Methodist | 35 | at | Guilford | 61 | @ ODC | |||
| Birmingham-Southern | 41 | at | Huntingdon AL | 35 | SAA | |||
| Berry | 34 | at | LaGrange | 21 | SAA | |||
| Centre | 40 | at | Maryville | 6 | SAA | |||
| Averett | 14 | at | Randolph-Macon | 24 | @ ODC | |||
| North Carolina Wesleyan | 21 | at | Shenandoah | 59 | @ ODC | |||
| 9/15/2018 | Ferrum | vs | Averett | PPD | vs ODC | |||
| Allen | vs | Brevard | CCD | vs NAIAInd (NAIA) | ||||
| Methodist | vs | Emory & Henry | CCD | vs ODC | ||||
| Maryville | at | Washington and Lee | CCD | @ ODC | ||||
| 9/20/2018 | Maryville | at | Washington and Lee | CCD | @ ODC | |||
| 9/21/2018 | North Carolina Wesleyan | at | Bridgewater VA | PPD | @ ODC | |||
| 9/22/2018 | Greensboro | 0 | at | Ferrum | 81 | @ ODC | ||
| Thomas More | 38 | at | Huntingdon AL | 35 | D3Ind | |||
| Apprentice | 13 | at | LaGrange | 42 | D3Ind | |||
| Brevard | 14 | at | Virginia U-Lynchburg | 16 | @ None (Unk?) | |||
| 9/29/2018 | Greensboro | 0 | at | Averett | 54 | |||
| Brevard | 3 | at | Maryville | 29 | ||||
| Huntingdon AL | 34 | at | Methodist | 48 | ||||
| LaGrange | 14 | at | North Carolina Wesleyan | 35 | ||||
| 10/6/2018 | Methodist | 36 | at | Brevard | 41 | |||
| North Carolina Wesleyan | 38 | at | Greensboro | 0 | ||||
| Averett | 38 | at | LaGrange | 14 | ||||
| Huntingdon AL | 13 | at | Maryville | 42 | ||||
| 10/13/2018 | Brevard | 17 | at | Huntingdon AL | 52 | |||
| Maryville | 34 | at | Methodist | 9 | ||||
| Averett | 24 | at | North Carolina Wesleyan | 14 | ||||
| 10/14/2018 | LaGrange | 43 | at | Greensboro | 16 | |||
| 10/20/2018 | Huntingdon AL | 17 | at | Averett | 45 | |||
| North Carolina Wesleyan | 29 | at | Brevard | 21 | ||||
| Maryville | 37 | at | LaGrange | 17 | ||||
| Greensboro | 6 | at | Methodist | 42 | ||||
| 10/27/2018 | LaGrange | 34 | at | Brevard | 38 | |||
| Greensboro | 0 | at | Huntingdon AL | 45 | ||||
| Averett | 0 | at | Maryville | 14 | ||||
| Methodist | 10 | at | North Carolina Wesleyan | 37 | ||||
| 11/3/2018 | Brevard | 6 | at | Averett | 25 | |||
| Maryville | 42 | at | Greensboro | 7 | ||||
| Methodist | 38 | at | LaGrange | 48 | ||||
| Huntingdon AL | 50 | at | North Carolina Wesleyan | 29 | ||||
| 11/10/2018 | Greensboro | 7 | at | Brevard | 28 | |||
| LaGrange | 14 | at | Huntingdon AL | 42 | ||||
| North Carolina Wesleyan | 14 | at | Maryville | 31 | ||||
| Averett | 22 | at | Methodist | 13 | ||||
| 11/17/2018 | Ferrum | 13 | at | Averett | 20 | ODC | ||
| Maryville | 0 | at | Berry | 31 | D3 Playooff Round 1 | @ SAA | ||
| Allen | 10 | at | Brevard | 46 | NAIAInd (NAIA) | |||
| North Carolina Wesleyan | 14 | at | Bridgewater VA | 21 | @ ODC |