| 9/1/2018 | Huntingdon AL (4-5) | at | Guilford | CCD | USASC | |||
| 9/8/2018 | Methodist (2-7) | 35 | at | Guilford | 61 | USASC | ||
| 9/13/2018 | Guilford | 61 | at | Davidson (6-5) | 91 | at Pio | ||
| 9/29/2018 | Bridgewater VA (6-4,4-3) | 30 | at | Guilford | 28 | |||
| 10/6/2018 | Guilford | 34 | at | Randolph-Macon (9-3,6-1) | 63 | |||
| 10/12/2018 | Ferrum (5-5,3-4) | 27 | at | Guilford | 28 | |||
| 10/20/2018 | Guilford | 35 | at | Hampden-Sydney (4-5,4-3) | 38 | |||
| 10/27/2018 | Washington and Lee (5-4,3-4) | 3 | at | Guilford | 40 | |||
| 11/3/2018 | Guilford | 47 | at | Shenandoah (5-5,3-4) | 62 | |||
| 11/10/2018 | Guilford | 27 | at | Emory & Henry (4-5,3-4) | 70 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 6-3 | 44-45 | |
| Points Scored: | 46.56 | 33.49 | -13.07 |
| Points Allowed: | 40.11 | 31.37 | 8.74 |
| Margin: | 6.45 | 2.12 | -4.33 |
| Total Points: | 86.67 | 64.86 | 21.81 |