| 8/30/2018 | North Greenville | 13 | at | Tusculum | 3 | GSC | ||
| Lenoir-Rhyne | 32 | at | West Alabama | 36 | @ GSC | |||
| Carson-Newman | 9 | at | West Florida | 19 | @ GSC | |||
| Johnson C Smith | 0 | at | Wingate | 36 | CIAA | |||
| 9/1/2018 | Mars Hill | 7 | at | East Tennessee St | 28 | @ SoCon (1AA) | ||
| Limestone | 17 | at | Gardner-Webb | 52 | @ BigS (1AA) | |||
| Catawba | 3 | at | West Georgia | 34 | @ GSC | |||
| Newberry | 26 | at | Western Carolina | 33 | @ SoCon (1AA) | |||
| 9/8/2018 | Newberry | 10 | at | Florida Tech | 17 | @ GSC | ||
| Shaw | 27 | at | Mars Hill | 9 | CIAA | |||
| Lenoir-Rhyne | 51 | at | North Greenville | 24 | @ GSC | |||
| Tusculum | 61 | at | Shorter | 14 | @ GSC | |||
| Carson-Newman | 33 | at | Virginia Union | 29 | @ CIAA | |||
| Limestone | 14 | at | West Georgia | 42 | @ GSC | |||
| Fayetteville State | 13 | at | Wingate | 27 | CIAA | |||
| Catawba | 34 | at | Winston-Salem State | 7 | @ CIAA | |||
| 9/13/2018 | Mars Hill | 27 | at | Lenoir-Rhyne | 59 | |||
| Virginia U-Lynchburg | 14 | at | Newberry | 27 | None (Unk?) | |||
| 9/14/2018 | Limestone | 10 | at | Tusculum | 37 | |||
| 9/15/2018 | Wingate | 14 | at | Carson-Newman | 31 | |||
| UNC Pembroke | vs | Catawba | CCD | vs D2Ind | ||||
| 9/22/2018 | West Alabama | 16 | at | Limestone | 13 | GSC | ||
| Catawba | 33 | at | Mars Hill | 39 | ||||
| Carson-Newman | 3 | at | Newberry | 23 | ||||
| UNC Pembroke | at | Tusculum | CCD | D2Ind | ||||
| Lenoir-Rhyne | 31 | at | Wingate | 24 | ||||
| 9/29/2018 | Carson-Newman | 33 | at | Catawba | 30 | OT | ||
| Tusculum | 10 | at | Lenoir-Rhyne | 35 | ||||
| Mars Hill | 51 | at | Limestone | 41 | ||||
| Newberry | 20 | at | UNC Pembroke | 0 | @ D2Ind | |||
| Florida Tech | 26 | at | Wingate | 23 | GSC | |||
| 10/6/2018 | Limestone | 24 | at | Carson-Newman | 52 | |||
| Albany State GA | 35 | at | Catawba | 21 | SIAC | |||
| Tusculum | 31 | at | Mars Hill | 28 | ||||
| Lenoir-Rhyne | 34 | at | Newberry | 21 | ||||
| Wingate | 51 | at | UNC Pembroke | 7 | @ D2Ind | |||
| 10/13/2018 | Mars Hill | 27 | at | Carson-Newman | 49 | |||
| Limestone | 17 | at | Lenoir-Rhyne | 63 | ||||
| Newberry | 0 | at | Tusculum | 14 | ||||
| Catawba | 25 | at | Wingate | 35 | ||||
| 10/20/2018 | Virginia U-Lynchburg | 10 | at | Carson-Newman | 63 | None (Unk?) | ||
| Tusculum | 37 | at | Catawba | 55 | ||||
| Lenoir-Rhyne | 30 | at | Fort Valley State | 22 | @ SIAC | |||
| Newberry | 29 | at | Limestone | 13 | ||||
| Mars Hill | 21 | at | Wingate | 58 | ||||
| 10/27/2018 | Limestone | 6 | at | Catawba | 43 | |||
| UNC Pembroke | 3 | at | Lenoir-Rhyne | 51 | D2Ind | |||
| Wingate | 31 | at | Newberry | 17 | ||||
| Carson-Newman | 28 | at | Tusculum | 41 | ||||
| 11/3/2018 | Lenoir-Rhyne | 40 | at | Carson-Newman | 21 | |||
| Wingate | 49 | at | Limestone | 26 | ||||
| Catawba | 10 | at | Newberry | 40 | ||||
| Mars Hill | 34 | at | UNC Pembroke | 21 | @ D2Ind | |||
| Tusculum | 11 | at | VMI | 20 | @ SoCon (1AA) | |||
| 11/10/2018 | Catawba | 21 | at | Lenoir-Rhyne | 63 | |||
| Newberry | 17 | at | Mars Hill | 21 | ||||
| Carson-Newman | 34 | at | UNC Pembroke | 13 | @ D2Ind | |||
| Tusculum | 12 | at | Wingate | 16 | ||||
| 11/17/2018 | UNC Pembroke | 23 | at | Catawba | 30 | D2Ind | ||
| Florida Tech | 21 | at | Lenoir-Rhyne | 43 | D2 Playoff Round 1 | GSC | ||
| Wingate | 41 | at | West Georgia | 31 | D2 Playoff Round 1 | @ GSC | ||
| 11/24/2018 | Wingate | 17 | at | Lenoir-Rhyne | 21 | |||
| 12/1/2018 | Lenoir-Rhyne | 21 | at | Valdosta State | 61 | D2 Playoff | @ GSC |